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Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 7312938, 8 pages
https://doi.org/10.1155/2017/7312938
Research Article

The Anti-Inflammatory Effects of a Yin Zhi Huang Soup in an Experimental Autoimmune Prostatitis Rat Model

1Department of Andrology, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, China
2Department of Clinical Foundation of TCM, Fujian University of Traditional Chinese Medicine, Fuzhou, China

Correspondence should be addressed to Longsheng Deng

Received 2 July 2017; Revised 24 October 2017; Accepted 22 November 2017; Published 21 December 2017

Academic Editor: Ken Yasukawa

Copyright © 2017 Longsheng Deng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study aimed to investigate the therapeutic effects of the Chinese herbal medicine Yin Zhi Huang soup (YZS) in an experimental autoimmune prostatitis (EAP) rat model. In total, 48 rats were randomly divided into the following four groups (/group): saline group, pathological model group, Qianlietai group, and YZS group. We determined the average wet weight of the prostate tissue, the ratio of the wet weight of the prostate tissue to body weight, tumor necrosis factor-alpha (TNF-α) levels in the blood serum, the expression of inducible nitric oxide synthase (iNOS) in the rats’ prostate tissues, and the pathological changes in the prostate tissue using light microscopy. YZS reduced the rats’ prostate wet weight, the ratio of the prostate wet weight to body weight, and TNF-α levels in the blood serum and inhibited the expression of iNOS in the rats’ prostate tissues (). Following YZS treatment, the pathological changes in the rats’ prostates were improved compared with those in the model group (). Furthermore, YZS treatment reduced inflammatory changes in the prostate tissue. It also significantly suppressed proinflammatory cytokines, such as TNF-α, and chemokines, such as iNOS, in the rat model of EAP.