Preventive Effects of a Chinese Herbal Formula, Shengjiang Xiexin Decoction, on Irinotecan-Induced Delayed-Onset Diarrhea in Rats

Figure 5

Effects of SXD on the intestinal mucosa of rats after irinotecan administration (HE ×100). (a) Blank control group: the architecture of the intestinal epithelium has integrity and intestinal crypts and villi can be seen clearly. (b) Model control group: the architecture of the epithelium is destroyed, epithelial cell arrangement is disordered, and intestinal crypts and villi are reduced. (c) Low-dose SXD group, (d) middle-dose SXD group, and (e) high-dose SXD group: intestinal crypts are maintained; the general architecture of the epithelium and the outline of the intestinal villi can be seen indistinctly.

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