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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 7382752, 10 pages
Research Article

Metabolomics Analysis for Defining Serum Biochemical Markers in Colorectal Cancer Patients with Qi Deficiency Syndrome or Yin Deficiency Syndrome

1Department of Immunology and Microbiology, Basic Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
2Department of Traditional Chinese Medicine, Taizhou First People’s Hospital, Taizhou, Zhejiang, China
3Department of Internal Medicine, Yuyao Hospital of Traditional Chinese Medicine, Yuyao, Zhejiang, China
4Department of Medical Oncology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, Zhejiang, China
5Department of Medical Oncology, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

Correspondence should be addressed to Shanming Ruan; moc.361@32-mhtyhr

Received 4 February 2017; Revised 1 May 2017; Accepted 22 May 2017; Published 24 July 2017

Academic Editor: Waris Qidwai

Copyright © 2017 Fangfang Tao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Colorectal cancer is one of the leading causes of tumor-associated death, and traditional Chinese medicine (TCM) classifies colorectal cancer into various subtypes mainly according to the symptomatic pattern identification (ZHENG). Here, we investigated the difference in metabolic profiles of serum by comparing colorectal cancer subjects with Nondeficiency (ND), Qi deficiency (QD), and Yin deficiency (YD). The ratio of subjects with carcinoembryonic antigen (CEA) was higher in YD pattern, and the ratio of subjects with carbohydrate antigen 19-9 (CA19-9) was higher both in YD and in QD, compared with ND. As a result of metabolomics analysis, twenty-five metabolites displayed differences between QD and ND, while twenty-eight metabolites displayed differences between YD and ND. The downregulated metabolites in QD/ND and YD/ND mainly include carbohydrates and the upregulated metabolites mainly include amino acids and fatty acids, suggesting conversion obstruction of carbohydrates, fatty acids, and amino acids occurs in patients with QD and YD compared with ND. Our results demonstrate that colorectal cancer patients with QD or YD were associated with metabolic disorders and the variations of serum metabolic profiles may serve as potential biochemical markers for diagnosis and prognosis of colorectal cancer patients displayed QD or YD patterns.