Ficus hispida Bark Extract Prevents Nociception, Inflammation, and CNS Stimulation in Experimental Animal Model
Table 4
Effects of EFHB on hot plate test in mice.
Treatment
Dose (mg/kg)
Latency period (s) (% MPE)
0 min
30 min
45 min
60 min
90 min
120 min
Vehicle
10 (ml/kg)
2.19 ± 0.19
2.40 ± 0.16
2.42 ± 0.23
2.47 ± 0.34
2.39 ± 0.38
2.69 ± 0.45
Morphine
5
2.38 ± 0.21
10.63 ± 0.65 (41.15
10.31 ± 0.57 (39.31
10.98 ± 0.69 (42.71
9.92 ± 0.54 (34.86
5.27 ± 0.30 (11.08
EFHB
100
2.24 ± 0.22
2.71 ± 0.19 (2.64
3.45 ± 0.53 (6.78
3.87 ± 0.75 (9.74
4.23 ± 0.49 (11.21
3.91 ± 0.56 (9.74
EFHB
200
2.29 ± 0.23
2.93 ± 1.56 (3.83
3.71 ± 0.61 (8.23
4.51 ± 0.60 (12.73
5.31 ± 0.53 (17.24
3.97 ± 0.60 (9.35
EFHB
400
2.37 ± 0.19
3.89 ± 0.43 (8.60
5.60 ± 0.59 (18.31
7.67 ± 0.58 (18.16
6.78 ± 0.54 (19.30
5.13 ± 0.35 (12.26
NLX
2
2.65 ± 0.35
2.51 ± 0.51
2.65 ± 0.34
2.39 ± 0.26
2.58 ± 0.38
1.77 ± 0.28
NLX + morphine
2 + 5
2.90 ± 0.31
2.59 ± 0.43 (−2.02
3.92 ± 0.27 (0.74
2.76 ± 0.27 (−0.72
2.31 ± 0.22 (−3.64
2.88 ± 0.26 (−0.63
NLX + EFHB
2 + 100
2.97 ± 0.32
2.30 ± 0.27 (−3.42)
2.21 ± 0.47 (−4.01
2.27 ± 0.64 (−1.35
2.65 ± 0.83 (−1.07
2.97 ± 0.31 (−0.04
NLX + EFHB
2 + 200
2.35 ± 0.20
2.19 ± 0.14 (1.11
2.18 ± 0.56 (−0.33
2.59 ± 0.62 (1.21
2.66 ± 0.79 (−0.27
2.18 ± 0.26 (−0.99
NLX + EFHB
2 + 400
2.71 ± 0.71
2.87 ± 0.30 (2.07)
3.22 ± 0.44 (3.34
3.10 ± 0.58 (2.44
2.91 ± 0.48 (1.28
2.27 ± 0.18 (−3.49
Here, each value is presented as the mean ± SEM . EFHB = ethanol extract of Ficus hispida. NLX = naloxone, MPE = Maximum Possible Effect. Indicating compared with control group (Dunnett’s test). Indicating compared with control group (Dunnett’s test). Indicating compared with morphine group (Bonferroni’s test). Indicating compared with morphine group (Bonferroni’s test). Indicating compared with morphine group (Bonferroni’s test). Indicating compared with morphine group (Bonferroni’s test).
