Poly-ε-Caprolactone Microsphere Polymers Containing Usnic Acid: Acute Toxicity and Anti-Inflammatory Activity

Table 3

Anti-inflammatory effect of free usnic acid (UA), encapsulated usnic acid microspheres (UA-micro), and indomethacin on carrageenan induced rat paw edema model (n = 5 animals/group).

Groups	Variation of paw volume (mL)
	60 min	120 min	180 min	240 min
Vehicle (control)	0.61 ± 0.05	1.25 ± 0.09	1.62 ± 0.09	1.30 ± 0.07
UA 25 mg/kg	0.32 ± 0.02	0.50 ± 0.04	1.10 ± 0.11	0.81 ± 0.14
UA-micro 25 mg/kg	0.30 ± 0.03	0.45 ± 0.05	0.87 ± 0.06	0.68 ± 0.05
UA-micro 50 mg/kg	0.26 ± 0.01	0.40 ± 0.03	0.63 ± 0.03	0.48 ± 0.03
Indomethacin 10 mg/kg	0.18 ± 0.02	0.30 ± 0.03	0.40 ± 0.03	0.29 ± 0.02

Values are expressed as mean ± SD (n = 5/group). Significantly different from the control group, (control versus UA 25 mg/kg; UA-micro 25 mg/kg; and UA-micro 50 mg/kg). ^#Significantly different from the UA 25 mg/kg group, (UA 25 mg/kg versus UA-micro 25 mg/kg and UA-micro 50 mg/kg).