Poly-ε-Caprolactone Microsphere Polymers Containing Usnic Acid: Acute Toxicity and Anti-Inflammatory Activity

Table 4

Effect of free usnic acid (UA) and encapsulated usnic acid microspheres (UA-micro) on neutrophils migration.

Groups	Dose (mg/kg p.o.)	Leukocytes migration (10^3/mm^3)	Inhibition%
Control	—	11.4 ± 1.17	—
UA	25	5.8 ± 0.68	49
UA-micro	25	7.8 ± 0.67	31
UA-micro	50	3.8 ± 0.49	67
Indomethacin	10	3.6 ± 0.76	68

Data are shown as mean ± SD (n = 5/group) and the statistical significance between groups was determined using Analysis of Variance (ANOVA) followed by Turkey’s test. < 0,0001 versus control. ^#Nonsignificant versus indomethacin.