Research Article

Identification of Tengfu Jiangya Tablet Target Biomarkers with Quantitative Proteomic Technique

Table 1

The molecular function, biological process, and expression levels of 20 candidate serum proteins quantified by iTRAQ technique.

Protein IDProtein nameMolecular_functionBiological processEH/TJT (mean)

sp|P18428Lipopolysaccharide-binding proteinReceptor binding
Lipoteichoic acid binding
Positive regulation of chemokine production
Leukocyte chemotaxis involved in inflammatory; acute-phase response
0.789

tr|Q5SRP5Apolipoprotein MLipid transporter activity
Antioxidant activity
Response to glucose stimulus0.6995

tr|F1C4A7Monocyte differentiation antigen CD14Lipoteichoic acid binding
Lipopolysaccharide binding
Opsonin receptor
Positive regulation of cytokine secretion
Apoptotic process
Inflammatory response
0.5385

tr|D6REX5Selenoprotein PSelenium bindingResponse to oxidative stress0.8125

tr|A0A024R1G8Apolipoprotein L, 1Lipid binding
Protein binding
Chloride channel activity
Chloride transport
Cytolysis
0.342

tr|H6VRF8Keratin 1receptor activity
protein binding
response to oxidative stress
regulation of angiogenesis
epidermis development
0.533

tr|Q1HP67Lipoprotein, Lp(A)Serine-type endopeptidase activity
Protein domain specific binding
Negative regulation of cell proliferation
Proteolysis
Negative regulation of cell proliferation
0.4515

tr|C0JYY2Apolipoprotein BReceptor binding
Enzyme binding
ā€‰0.396

tr|D3DNU8Kininogen 1Receptor binding
Zinc ion binding
Heparin binding
Cysteine-type endopeptidase inhibitor activity
Elevation of cytosolic calcium ion
Positive regulation of renal sodium excretion;
Smooth muscle contraction;
Vasodilation;
inflammatory response
0.796

tr|J3KPY9Anthrax toxin receptor 2Receptor activity
Protein binding
Receptor-mediated endocytosis
Artery morphogenesis
Low-density lipoprotein particle remodeling
0.4945

tr|V9GYG9Apolipoprotein A-IIProtein homodimerization activity bindingResponse to glucocorticoid stimulus
Protein oxidation
Acute inflammatory response
0.609

tr|B3KUE5Phospholipid transfer proteinLipid bindingVitamin E biosynthetic process
Lipid metabolic process
0.441

sp|P05164MyeloperoxidasePeroxidase activity heme bindingHydrogen peroxide catabolic process
Oxidation-reduction process
1.868

tr|Q6UXM4Ficolin 3Receptor bindingSignal transduction
Complement activation, lectin pathway
1.219

tr|F8VV32Lysozyme CLysozyme activityInflammatory1.5085

tr|Q5VY30Retinol binding protein 4Retinol transporter activity protein bindingPositive regulation of insulin secretion
Positive regulation of immunoglobulin secretion; negative regulation of endopeptidase activity
Peptidyl-glutamic acid carboxylation
1.856

tr|A0A024RDB8HeparanaseBeta-glucuronidase activity heparanase activityVascular wound healing; regulation vascular endothelial growth factor production
Glycosaminoglycan catabolic process
1.449

tr|D3DQX7Serum amyloid A proteinG-protein coupled receptor bindingAcute-phase response; negative regulation of inflammatory response
Neutrophil chemotaxis
1.2535

tr|X6RLJ0Complement C1q subcomponent subunit AProtein bindingComplement activation, classical pathway
Cell-cell signaling
1.216

tr|A0A087WT59TransthyretinProtein bindingā€”1.1655