Research Article

Optimized-SopungSunkiwon, a Herbal Formula, Attenuates Aβ Oligomer-Induced Neurotoxicity in Alzheimer’s Disease Models

Figure 4

Effect of OSS on -induced memory impairment. Mice were treated with vehicle or OSS for 14 days, starting from 5 days before stereotaxic injection of . NORT was carried out at 7 (training session) and 8 (test session) days after injection (a). PAT was conducted at 9 (acquisition trial) and 10 (retention trial) days after injection (b). The -injected group treated with OSS exhibited significantly ameliorating memory impairment induced by stress. Values are indicated as the mean ± SEM. compared to sham-operated group; , , and compared to the -only treated group.