Schisandra chinensis and Morus alba Synergistically Inhibit In Vivo Thrombus Formation and Platelet Aggregation by Impairing the Glycoprotein VI Pathway

Figure 5

(a) The inhibitory effect of SCC + MAL on fibrinogen binding to integrin . Washed platelets (3 × 10⁸/mL) were preincubated for 2 min at room temperature in the presence of 0.1 mM CaCl₂, stimulated with collagen for 5 min and fibrinogen Alexa Fluor 488 (20 μg/mL), and then fixed with 0.5% paraformaldehyde at 4°C for 30 min. Representative FACS analysis results of four independent trials are shown. Basal (A), 5 µg/mL of collagen (B), and 400 µg/mL of SCC + MAL (C). (b) Bar graph summarizing the inhibitory effect of SCC + MAL extract on fibrinogen binding. compared to the agonist control.

(a)

(b)