5,7-Dihydroxyflavone Analogues May Regulate Lipopolysaccharide-Induced Inflammatory Responses by Suppressing I<i>κ</i>B<i>α</i>-Linked Akt and ERK5 Phosphorylation in RAW 264.7 Macrophages

<div>The suggested pathway of inflammatory reaction [<a href="/journals/ecam/2017/7898973/#B44">16</a>] and a tentative mechanism of anti-inflammation by 5,7-dihydroxyflavones. They significantly suppressed the phosphorylation of I<i>κ</i>B<i>α</i> by inhibition of both ERK5 and Akt phosphorylation and inhibition of NF<i>κ</i>B activity, resulting in the inhibition of iNOS and COX2 production. TLR: toll-like receptor, Ub: ubiquitin, and P: phosphoric acid.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 7: 5,7-Dihydroxyflavone Analogues May Regulate Lipopolysaccharide-Induced Inflammatory Responses by Suppressing I<i>κ</i>B<i>α</i>-Linked Akt and ERK5 Phosphorylation in RAW 264.7 Macrophages 

Figure 7 | 5,7-Dihydroxyflavone Analogues May Regulate Lipopolysaccharide-Induced Inflammatory Responses by Suppressing IκBα-Linked Akt and ERK5 Phosphorylation in RAW 264.7 Macrophages 