Huanglian-Jie-Du-Tang Extract Ameliorates Depression-Like Behaviors through BDNF-TrkB-CREB Pathway in Rats with Chronic Unpredictable Stress

Figure 11

Effect of HJDT on the 5-HT and DA contents in the hippocampus after the CUS. The contents of 5-HT (a) and DA (b) decreased in CUS depression group. Paroxetine treatment only increased the 5-HT content (a) and there was no effect on DA content (b) in the hippocampus. There was no effect of HJDT on the contents of 5-HT and DA in the hippocampus (a, b). and relative to the normal control group; relative to the CUS depression group. N: normal control group; D: CUS depression group; P: paroxetine group; HJDT 2: HJDT 2 g/kg group; HJDT 4: HJDT 4 g/kg group; HJDT 8: HJDT 8 g/kg group.

(a)

(b)