Huanglian-Jie-Du-Tang Extract Ameliorates Depression-Like Behaviors through BDNF-TrkB-CREB Pathway in Rats with Chronic Unpredictable Stress

Figure 5

Effects of HJDT on the exploration time, DR, and DI in NORT after the CUS. The exploration time to novel object increased compared with familiar object in T₂ phase in normal control group, paroxetine group, and HJDT (2, 4 g/kg) groups (a). DR (b) and DI (c) in T₂ phase significantly increased in normal control group, paroxetine group, and HJDT (2, 4 g/kg) groups compared to T₁ phase. relative to the familiar object in T₂ test (a); relative to T₁ phase in the same group (b-c). N: normal control group; D: CUS depression group; P: paroxetine group; HJDT 2: HJDT 2 g/kg group; HJDT 4: HJDT 4 g/kg group; HJDT 8: HJDT 8 g/kg group.

(a)

(b)

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