Huanglian-Jie-Du-Tang Extract Ameliorates Depression-Like Behaviors through BDNF-TrkB-CREB Pathway in Rats with Chronic Unpredictable Stress

Figure 8

Effect of HJDT on the BDNF, TrkB, and pCREB/CREB expression in the hippocampus after the CUS. The expression of BDNF (a), TrkB (b), and pCREB/CREB (c) decreased in the CUS depression group and was reversed with paroxetine and HJDT (2, 4 g/kg) treatment. Protein expression is induced by CUS and drug treatment in the hippocampus (d). and relative to the normal control group; and relative to the CUS depression group. N: normal control group; D: CUS depression group; P: paroxetine group; HJDT 2: HJDT 2 g/kg group; HJDT 4: HJDT 4 g/kg group; HJDT 8: HJDT 8 g/kg group.

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