Research Article
Optimal Solubility of Diclofenac β-Cyclodextrin in Combination with Local Anaesthetics for Mesotherapy Applications
Table 2
The table reports the Akis + anaesthetic combinations resulting in limpid or turbid solutions.
| | Akis (final dilution in brackets) | Vehicle | Anaesthetic (final dilution in brackets) |
| 25 mg/mL, 1 mL
(5 mg/mL) | Bicarbonate 3 mL | Lidocaine 1% 1 mL (0.2%) | Limpid | | Bicarbonate 2 mL | Lidocaine 1% 2 mL (0.4%) | Limpid | | Bicarbonate 3 mL | Lidocaine 2% 1 mL (0.4%) | Limpid |
| 50 mg/mL, 1 mL
(10 mg/mL) | Bicarbonate 3 mL | Lidocaine 1% 1 mL (0.2%) | Limpid | | Bicarbonate 2 mL | Lidocaine 1% 2 mL (0.4%) | Limpid | | Bicarbonate 3 mL | Lidocaine 2% 1 mL (0.4%) | Limpid |
| 25 mg/mL, 1 mL
(5 mg/mL) | Bicarbonate 3 mL | Mepivacaine 1% 1 mL (0.2%) | Limpid | | Bicarbonate 2 mL | Mepivacaine 1% 2 mL (0.4%) | Limpid | | Bicarbonate 3 mL | Mepivacaine 2% 1 mL (0.4%) | Limpid |
| 50 mg/mL, 1 mL
(10 mg/mL) | Bicarbonate 3 mL | Mepivacaine 1% 1 mL (0.2%) | Limpid | | Bicarbonate 2 mL | Mepivacaine 1% 2 mL (0.4%) | Limpid | | Bicarbonate 3 mL | Mepivacaine 2% 1 mL (0.4%) | Limpid |
| 25 mg/mL, 1 mL
(5 mg/mL) | Bicarbonate 3 mL | Bupivacaine 0.25% 1 mL (0.05%) | Limpid | | Bicarbonate 3 mL | Bupivacaine 0.5% 1 mL (0.1%) | Turbid |
| 50 mg/mL, 1 mL
(10 mg/mL) | Bicarbonate 3 mL | Bupivacaine 0.25% 1 mL (0.05%) | Limpid | | Bicarbonate 2 mL | Bupivacaine 0.25% 2 mL (0.1%) | Turbid |
| 25 mg/mL, 1 mL
(5 mg/mL) | Normal saline 3 mL | Ropivacaine 0.2% 1 mL (0.04%) | Turbid | | Sterile water 3 mL | Ropivacaine 0.2% 1 mL (0.04%) | Turbid | | Bicarbonate 3 mL | Ropivacaine 0.2% 1 mL (0.4%) | Turbid |
| 50 mg/mL, 1 mL
(10 mg/mL) | Normal saline 3 mL | Ropivacaine 0.2% 1 mL (0.04%) | Turbid | | Sterile water 3 mL | Ropivacaine 0.2% 1 mL (0.04%) | Turbid | | Bicarbonate 3 mL | Ropivacaine 0.2% 1 mL (0.4%) | Turbid |
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