Research Article

Extract from Periostracum cicadae Inhibits Oxidative Stress and Inflammation Induced by Ultraviolet B Irradiation on HaCaT Keratinocytes

Figure 5

Effect of topical treatment of mouse skin with P. cicadae on UVB-induced damage. (a) ICR mice skin was treated with either 200 μg/mL P. cicadae or PBS and was exposed to UVB every 5 days, as described in Methods. Mouse skin treated topically with P. cicadae before UVB exposure reduced UVB-induced signs of sunburn tissue damage. (b) Skin biopsies were processed by H&E staining by a routine procedure. Micrographs show representative findings of skin in response to UVB, sampled after UVB exposure, and a representative section of H&E staining from three independent experiments is shown. Pretreatment of P. cicadae inhibited UVB-induced extensive structural damage in both epidermis and dermis (magnification, 40x).
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