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Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 8350320, 9 pages
https://doi.org/10.1155/2017/8350320
Review Article

Brazilian Amazon Traditional Medicine and the Treatment of Difficult to Heal Leishmaniasis Wounds with Copaifera

1Programa de Pós-Graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, PA, Brazil
2Programa de Pós-Graduação em Inovação Farmacêutica, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, PA, Brazil
3Faculdade de Química, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém, PA, Brazil
4Laboratório de Estresse Oxidativo, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil

Correspondence should be addressed to Maria Fâni Dolabela

Received 13 August 2016; Accepted 25 October 2016; Published 17 January 2017

Academic Editor: Chiranjib Pal

Copyright © 2017 Kelly Cristina Oliveira de Albuquerque et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. WHO, Strategic Direction for Research: Leishmaniasis. Special Programme for Research and Training in Tropical Diseases, World Health Organization, Tropical Diseases Research (TDR), Geneva, Switzerland, 2002.
  2. WHO, Leishmaniasis—A Brief History of the Disease, World Health Organization, Geneva, Switzerland, 2014, http://apps.who.int/iris/bitstream/10665/111008/1/WHO_DCO_WHD_2014.1_eng.pdf.
  3. C. A. Paraguassu-Chaves, Geografia Médica ou da Saúde (Espaço e doença na Amazônia Ocidental), Edufro, 1st edition, 2001.
  4. B. Gontijo and M. L. R. Carvalho, “American cutaneous leishmaniasis,” Journal of the Brazilian Society of Tropical Medicine, vol. 36, no. 1, pp. 71–80, 2003. View at Google Scholar
  5. Brazil, Ministry of Health, Department of Health, and Secretary of Surveillance in Health, Manual of Surveillance of American Tegumentary Leishmaniasis, House of the Ministry of Health, Brasília, Brazil, 2th edition, 2010.
  6. A. G. L. Oliveira, Influência do Estado Nutricional na Evolução Clínica e Terapêutica de Adultos e Idosos com Leishmaniose Tegumentar Americana [M.S. dissertation], Fundação Oswaldo Cruz, Rio de Janeiro, Brazil, 2013.
  7. A. C. B. Carvalho and D. Silveira, “Drogas vegetais: uma antiga nova forma de utilização de plantas medicinais,” Brasília Médica, vol. 48, no. 2, pp. 219–237, 2010. View at Google Scholar
  8. D. M. Silva and K. R. Mocelin, “O cuidado de enfermagem ao cliente portador de feridas sob a ótica do cuidado transcultural,” Nursing, vol. 9, no. 105, pp. 81–88, 2007. View at Google Scholar
  9. L. A. F. Paiva, K. M. De Alencar Cunha, F. A. Santos, N. V. Gramosa, E. R. Silveira, and V. S. N. Rao, “Investigation on the wound healing activity of oleo-resin from Copaifera langsdorffi in rats,” Phytotherapy Research, vol. 16, no. 8, pp. 737–739, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. A. O. Santos, T. Ueda-Nakamura, B. P. Dias Filho, V. F. Veiga Jr., A. C. Pinto, and C. V. Nakamura, “Effect of Brazilian copaiba oils on Leishmania amazonensis,” Journal of Ethnopharmacology, vol. 120, no. 2, pp. 204–208, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. L. N. Pinto, Plantas medicinais utilizadas por comunidades do município de Igarapé-Miri, Pará: etnofarmácia do município de Igarapé-Miri-PA [M.S. dissertation], Universidade Federal do Pará, Belém, Brazil, 2008.
  12. Center of the Workers of the Amazon (CTA), Processing Booklet for Non-Timber Products: Medicinal Plants of the Forest, Poronga Publishing House, Rio Branco, Brazil, 1996.
  13. V. F. Veiga Jr. and A. C. Pinto, “O Gênero Copaifera L.,” Química Nova, vol. 25, no. 2, pp. 273–286, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. V. Cascon and B. Gilbert, “Characterization of the chemical composition of oleoresins of Copaifera guianensis Desf., Copaifera duckei Dwyer and Copaifera multijuga Hayne,” Phytochemistry, vol. 55, no. 7, pp. 773–778, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. F. C. M. Rondon, C. M. L. Bevilaqua, M. P. Accioly et al., “In vitro efficacy of Coriandrum sativum, Lippia sidoides and Copaifera reticulata against Leishmania chagasi,” Brazilian Journal of Veterinary Parasitology, vol. 21, no. 3, pp. 185–191, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Estevez, D. Castillo, M. T. Pisango et al., “Evaluation of the leishmanicidal activity of plants used by Peruvian Chayahuita ethnic group,” Journal of Ethnopharmacology, vol. 114, no. 2, pp. 254–259, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. A. O. dos Santos, E. Izumi, T. Ueda-Nakamura, B. P. Dias-Filho, V. F. da Veiga-Júnior, and C. Vataru Nakamura, “Antileishmanial activity of diterpene acids in copaiba oil,” Memorias do Instituto Oswaldo Cruz, vol. 108, no. 1, pp. 59–64, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. V. F. Veiga Jr., L. Zunino, M. L. Patitucci, A. C. Pinto, and J. B. Calixto, “The inhibition of paw oedema formation caused by the oil of Copaifera multijuga Hayne and its fractions,” Journal of Pharmacy and Pharmacology, vol. 58, no. 10, pp. 1405–1410, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. F. D. F. Fernandes and E. D. P. S. Freitas, “Acaricidal activity of an oleoresinous extract from Copaifera reticulata (Leguminosae: Caesalpinioideae) against larvae of the southern cattle tick, Rhipicephalus (Boophilus) microplus (Acari: Ixodidae),” Veterinary Parasitology, vol. 147, no. 1-2, pp. 150–154, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. V. F. Veiga Jr., M. A. Andrade Jr., I. D. K. Ferraz, H. B. Christo, and A. C. Pinto, “Constituents from Copaifera officinalis L. seeds,” Acta Amazonica, vol. 37, no. 1, pp. 123–126, 2007. View at Google Scholar · View at Scopus
  21. J. F. Milani, J. F. Rocha, and S. P. Teixeira, “Oleoresin glands in copaiba (Copaifera trapezifolia Hayne: Leguminosae), a Brazilian rainforest tree,” Biblioteca Digital da Produção Intelectual—BDPI Trees, vol. 26, no. 3, pp. 769–775, 2012. View at Google Scholar
  22. G. Wood, C. H. LaWall, H. W. Youngken, A. Osol, I. Griffith, and L. Gershenfeld, The Dispensatory of the United States of America, J. B. Lippincott & Co, Philadelphia, Pa, USA, 22th edition, 1940.
  23. W. Mors and C. T. Rizzini, Useful Plants of Brazil, Holden-Day, San Francisco, Calif, USA, 1st edition, 1966.
  24. F. Pieri, M. Mussi, and M. Moreira, “Óleo de copaíba (Copaifera sp.): histórico, extração, aplicações industriais e propriedades medicinais,” Revista Brasileira de Plantas Medicinais, vol. 11, no. 4, pp. 465–472, 2009. View at Publisher · View at Google Scholar
  25. W. F. Braga, C. M. Rezende, O. A. C. Antunes, and A. C. Pinto, “Terpenoids from Copaiba cearensis,” Phytochemistry, vol. 49, no. 1, pp. 263–264, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. H. D. S. Falcão, I. O. Lima, V. L. Santos et al., “Review of the plants with anti-inflammatory activity studied in Brazil,” Brazilian Journal of Pharmacognosy, vol. 15, no. 4, pp. 381–391, 2005. View at Publisher · View at Google Scholar
  27. V. Salvador, História do Brasil: 1500–1627, Melhoramentos, 6th edition, 1975.
  28. J. A. Wenninger, R. L. Yates, and M. Dolinsky, “Sesquiterpene hydrocarbons of commercial copahyba balsam and American Cedarwood oils,” Journal of the AOAC International, vol. 50, no. 6, pp. 1304–1313, 1967. View at Google Scholar
  29. M. Calvin, “Hydrocarbons from plants: analytical methods and observations,” Naturwissenschaften, vol. 67, no. 11, pp. 525–533, 1980. View at Publisher · View at Google Scholar · View at Scopus
  30. A. A. Craveiro, A. G. Fernandes, C. H. S. Andrade, F. J. D. A. Matos, J. W. Alencar, and M. I. L. Machado, Óleos Essenciais de Plantas do Nordeste, UFC, Fortaleza, Brazil, 1st edition, 1981.
  31. M. Ferrari, U. M. Pagnoni, F. Pelizzoni, V. Lukeš, and G. Ferrari, “Terpenoids from Copaifera langsdorfii,” Phytochemistry, vol. 10, no. 4, pp. 905–907, 1971. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Morin, H. Pichard, H. Pichard, M. Caude, and R. Rosset, “Supercritical fluid chromatography of sesquiterpene hydrocarbons on silica packed columns with on-line Fourier transform infrared detection,” Journal of Chromatography A, vol. 464, no. C, pp. 125–137, 1991. View at Publisher · View at Google Scholar · View at Scopus
  33. E. Stashenko, H. Wiame, S. Dassy, J. R. Martinez, and T. Shibamoto, “Catalytic transformation of copaiba (Copaifera officinalis) oil over zeolite ZSM-5,” Journal of High Resolution Chromatography, vol. 18, no. 1, pp. 54–58, 1995. View at Publisher · View at Google Scholar · View at Scopus
  34. V. F. Veiga Jr., Controle de qualidade de óleos de copaíba por cromatografia gasosa de alta resolução [M.S. dissertation], Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 1997.
  35. F. Delle Monache, F. Ferrari, I. L. D'Albuquerque, and G. B. Marini Bettolo, “Stereochemistry of proanthrocyanidine from Ouratea Sp. (Ochnaceae),” Il Farmaco; edizione scientifica, vol. 25, no. 2, pp. 96–105, 1970. View at Google Scholar · View at Scopus
  36. R. A. Spanevello and A. J. Vila, “7-α-Acetoxyhardwickiic acid: a furanoid clerodane,” Phytochemistry, vol. 35, no. 2, pp. 537–538, 1994. View at Publisher · View at Google Scholar · View at Scopus
  37. A. Ohsaki, L. T. Yan, S. Ito, H. Edatsugi, D. Iwata, and Y. Komoda, “The isolation and in vivo potent antitumor activity of clerodane diterpenoid from the oleoresin of the Brazilian medicinal plant, Copaifera langsdorfi desfon.,” Bioorganic and Medicinal Chemistry Letters, vol. 4, no. 24, pp. 2889–2892, 1994. View at Publisher · View at Google Scholar · View at Scopus
  38. H. Monti, N. Tiliacos, and R. Faure, “Two diterpenoids from copaiba oil,” Phytochemistry, vol. 42, no. 6, pp. 1653–1656, 1996. View at Publisher · View at Google Scholar · View at Scopus
  39. A. C. Pinto, O. A. C. Antunes, C. M. Rezende, and C. R. D. Correia, “Separation of acidic components of Vellozia flavicans by silica gel/potassium hydroxide chromatography,” Phytochemical Analysis, vol. 8, no. 1, pp. 14–17, 1997. View at Publisher · View at Google Scholar · View at Scopus
  40. A. C. Pinto, W. F. Braga, C. M. Rezende et al., “Separation of acid diterpenes of Copaifera cearensis Huber ex Ducke by flash chromatography using potassium hydroxide impregnated silica gel,” Journal of the Brazilian Chemical Society, vol. 11, no. 4, pp. 355–360, 2000. View at Publisher · View at Google Scholar · View at Scopus
  41. J. R. Mahajan and G. A. L. Ferreira, “New diterpenoids from copaiba oil,” Annals of the Brazilian Academy of Sciences, vol. 43, pp. 611–613, 1971. View at Google Scholar
  42. A. C. Basile, J. A. A. Sertié, P. C. D. Freitas, and A. C. Zanini, “Anti-inflammatory activity of oleoresin from Brazilian copaifera,” Journal of Ethnopharmacology, vol. 22, no. 1, pp. 101–109, 1988. View at Publisher · View at Google Scholar · View at Scopus
  43. R. M. Fernandes, N. A. Pereira, and L. G. Paulo, “Anti-inflammatory activity of copaiba balsam (Copaifera cearenses, Huber),” Brazilian Journal of Pharmacy, vol. 73, pp. 53–56, 1992. View at Google Scholar
  44. M. A. M. Maciel, A. C. Pinto, and V. F. Veiga Jr., “Medicinal plants: the need for multidisciplinary scientific studies,” Química Nova, vol. 25, no. 3, pp. 429–438, 2002. View at Publisher · View at Google Scholar · View at Scopus
  45. E. Estrella and M. Picasso Botto, Medicinal plants form the Amazon Region: reality and perspective [Monograph], Tratado de Cooperación Amazonica, Secretaria Pro Tempore, Lima, Peru, 1995.
  46. J. Revilla, Plantas da Amazônia: Oportunidades Econômicas e Sustentáveis, SEBRAE: INPA, 3rd edition, 2001.
  47. M. N. S. Rios and F. Pastore Junior, Plantas da Amazônia: 450 Espécies de Uso Geral, A Biblioteca Central da Universidade de Brasília, Brasilia, Brazil, 2011, http://leunb.bce.unb.br/handle/123456789/19.
  48. U. D. Oliveira, J. F. Marins, and S. J. R. Chiuchetta, “Avaliação do ciclo celular de Aspergillus nidulans exposto ao extrato da planta Copaifera officinalis L,” SaBios-Revista Saúde e Biologia, vol. 1, no. 2, pp. 42–47, 2005. View at Google Scholar
  49. V. F. Veiga Junior, A. C. Pinto, and M. A. M. Maciel, “Plantas medicinais: cura segura?” Química Nova, vol. 28, no. 3, pp. 519–528, 2005. View at Publisher · View at Google Scholar
  50. A. Ribeiro, Avaliação do potencial irritativo do óleo-resina de copaíba (substituto do eugenol) na fase exsudativa do processo inflamatório [M.S. thesis], Universidade de São Paulo, Bauru, Brazil, 1989.
  51. C. G. Sachetti, R. R. de Carvalho, F. J. R. Paumgartten, O. A. Lameira, and E. D. Caldas, “Developmental toxicity of copaiba tree (Copaifera reticulata Ducke, Fabaceae) oleoresin in rat,” Food and Chemical Toxicology, vol. 49, no. 5, pp. 1080–1085, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. J. M. Alves, C. C. Munari, M. de Azevedo Bentes Monteiro Neto et al., “In vivo protective effect of Copaifera langsdorffii hydroalcoholic extract on micronuclei induction by doxorubicin,” Journal of Applied Toxicology, vol. 33, no. 8, pp. 854–860, 2013. View at Publisher · View at Google Scholar · View at Scopus
  53. Â. G. Batista, A. S. Ferrari, D. C. Da Cunha et al., “Polyphenols, antioxidants, and antimutagenic effects of Copaifera langsdorffii fruit,” Food Chemistry, vol. 197, pp. 1153–1159, 2016. View at Publisher · View at Google Scholar · View at Scopus
  54. L. V. Costa-Lotufo, G. M. A. Cunha, P. A. M. Farias et al., “The cytotoxic and embryotoxic effects of kaurenoic acid, a diterpene isolated from Copaifera langsdorffii oleo-resin,” Toxicon, vol. 40, no. 8, pp. 1231–1234, 2002. View at Publisher · View at Google Scholar · View at Scopus
  55. C. Herrero-Jáuregui, M. A. Casado, M. Das Graças Bichara Zoghbi, and R. Célia Martins-Da-Silva, “Chemical variability of Copaifera reticulata ducke oleoresin,” Chemistry & Biodiversity, vol. 8, no. 4, pp. 674–685, 2011. View at Publisher · View at Google Scholar · View at Scopus
  56. WHO, Leishmaniasis, World Health Organization, Geneva, Switzerland, 2016, http://www.who.int/mediacentre/factsheets/fs375/en/.
  57. Brazil, Casos de Leishmaniose Tegumentar Americana. Brasil, grandes regiões e Unidades Federadas. 1990 a 2013, Brasília, Brazil, 2013, http://u.saude.gov.br/images/pdf/2014/setembro/09/LT-Casos.pdf.
  58. Brazil; Ministry of Health; Department of Health and Secretary of Surveillance in Health, Surveillance Manual and Control of Visceral Leishmaniasis, House of the Ministry of Health, Brasília, Brazil, 1st edition, 2003.
  59. D. C. Soares, N. A. Portella, M. F. Ramos, A. C. Siani, and E. M. Saraiva, “Trans-β-caryophyllene: an effective antileishmanial compound found in commercial copaiba oil (Copaifera spp.),” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 761323, 13 pages, 2013. View at Publisher · View at Google Scholar
  60. E. Izumi, T. Ueda-Nakamura, V. F. Veiga, A. C. Pinto, and C. V. Nakamura, “Terpenes from copaifera demonstrated in vitro antiparasitic and synergic activity,” Journal of Medicinal Chemistry, vol. 55, no. 7, pp. 2994–3001, 2012. View at Publisher · View at Google Scholar · View at Scopus
  61. G.-J. Feng, H. S. Goodridge, M. M. Harnett et al., “Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase,” The Journal of Immunology, vol. 163, no. 12, pp. 6403–6412, 1999. View at Google Scholar · View at Scopus
  62. R. L. Coffman, R. Correa-Oliviera, and S. Mocci, “Reversal of polarized T helper 1 and T helper 2 cell populations in murine leishmaniasis,” Ciba Foundation symposium, vol. 195, pp. 20–2533, 1995. View at Google Scholar · View at Scopus
  63. S. Nylén and L. Eidsmo, “Tissue damage and immunity in cutaneous leishmaniasis,” Parasite Immunology, vol. 34, no. 12, pp. 551–561, 2012. View at Publisher · View at Google Scholar · View at Scopus
  64. D. S. Lima-Junior, D. L. Costa, V. Carregaro et al., “Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania,” Nature Medicine, vol. 19, no. 7, pp. 909–915, 2013. View at Publisher · View at Google Scholar · View at Scopus
  65. J. Convit, M. Ulrich, C. T. Fernández et al., “The clinical and immunological spectrum of American cutaneous leishmaniasis,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 87, no. 4, pp. 444–448, 1993. View at Publisher · View at Google Scholar · View at Scopus
  66. A. P. Campanelli, C. I. Brodskyn, V. Boaventura et al., “Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis,” Human Immunology, vol. 71, no. 12, pp. 1220–1227, 2010. View at Publisher · View at Google Scholar · View at Scopus
  67. N. L. Díaz, O. Zerpa, and F. J. Tapia, “Chemokines and chemokine receptors expression in the lesions of patients with American cutaneous leishmaniasis,” Memórias do Instituto Oswaldo Cruz, vol. 108, no. 4, pp. 446–452, 2013. View at Publisher · View at Google Scholar · View at Scopus
  68. G. Valencia-Pacheco, E. N. Loría-Cervera, E. I. Sosa-Bibiano et al., “In situ cytokines (IL-4, IL-10, IL-12, IFN-γ) and chemokines (MCP-1, MIP-1α) gene expression in human Leishmania (Leishmania) mexicana infection,” Cytokine, vol. 69, no. 1, pp. 56–61, 2014. View at Publisher · View at Google Scholar · View at Scopus
  69. J. França-Costa, J. Van Weyenbergh, V. S. Boaventura et al., “Arginase I, polyamine, and prostaglandin E2 pathways suppress the inflammatory response and contribute to diffuse cutaneous leishmaniasis,” Journal of Infectious Diseases, vol. 211, no. 3, pp. 426–435, 2015. View at Publisher · View at Google Scholar · View at Scopus
  70. L. B. Samper, Envolvimento de CD200 na infectividade de isolados de Leishmania (leishmanial) amazonensis associados a leishmaniose cutânea localizada e leishmaniose cutânea difusa [M.S. thesis], Universidade de São Paulo, São Paulo, Brazil, 2015.
  71. G. M. Barton and R. Medzhitov, “Toll-like receptor signaling pathways,” Science, vol. 300, no. 5625, pp. 1524–1525, 2003. View at Publisher · View at Google Scholar · View at Scopus
  72. K. B. Santiago, B. J. Conti, B. F. Murbach Teles Andrade et al., “Immunomodulatory action of Copaifera spp oleoresins on cytokine production by human monocytes,” Biomedicine and Pharmacotherapy, vol. 70, pp. 12–18, 2015. View at Publisher · View at Google Scholar · View at Scopus
  73. L. V. Montes, L. P. Broseghini, F. S. Andreatta, M. E. S. Sant'Anna, V. M. Neves, and A. G. Silva, “Evidences for the use of copaiba oil-resin in wound healing—a systematic review,” Natureza on Line, vol. 7, no. 2, pp. 61–67, 2009. View at Google Scholar
  74. A. T. Cavalcanti Neto, T. E. P. Arruda, T. T. P. Arruda, S. L. S. Pereira, and E. Turatti, “Comparative evaluation between copaiba oil-resin and chlorhexidine digluconate on wound healing. Histological study in rats,” Revista de Odontologia da UNESP, vol. 34, no. 2, pp. 107–112, 2005. View at Google Scholar