Simultaneous Determination and Pharmacokinetic Study of Quercetin, Luteolin, and Apigenin in Rat Plasma after Oral Administration of Matricaria chamomilla L. Extract by HPLC-UV

Table 4

Stability of quercetin, luteolin, and apigenin in rat plasma ().

Compounds	Spiked conc. (μg/ml)	Short-term stability; (24 h at room temperature)		Long-term stability; (30 days at −20°C)		Freeze-thaw stability; (3 cycles)
		Found conc. (μg/ml)	RSD (%)	Found conc. (μg/ml)	RSD (%)	Found conc. (μg/ml)	RSD (%)
Quercetin	0.57		1.30		5.16		2.08
	2.84		5.68		5.17		2.78
	9.09		7.52		5.52		5.97
Luteolin	0.56		1.21		5.52		3.01
	2.80		4.65		5.03		5.23
	8.96		8.53		7.28		6.33
Apigenin	0.53		8.36		8.47		3.21
	2.65		6.14		5.07		5.31
	8.48		8.61		7.46		6.39