Danggui Buxue Extract-Loaded Liposomes in Thermosensitive Gel Enhance In Vivo Dermal Wound Healing via Activation of the VEGF/PI3K/Akt and TGF-β/Smads Signaling Pathway

Figure 5

Western blot analysis of vascular endothelial growth factor A (VEGFA) (a); phosphoinositide 3-kinase (PI3K), Akt, and p-Akt (b); transforming growth factor beta 1 (TGF-β1) (c); and Smad2/3, Smad4, and p-Smad2/3 (d) expression in wound granulation tissue from different treatment groups at each time point after injury ( = 3). (A) Western blot bands and (B) or (B–D) western blot analysis results are shown. < 0.05 versus model control; < 0.01 versus model control; < 0.001 versus model control; < 0.05 versus vehicle control; < 0.01 versus vehicle control; < 0.001 versus vehicle control. DBLTG, Danggui Buxue extract- (DBE-) loaded liposomes in thermosensitive gel; M, model control; V, vehicle control; D, DBLTG-treated.

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