Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 8407249, 13 pages
https://doi.org/10.1155/2017/8407249
Research Article

Danggui Buxue Extract-Loaded Liposomes in Thermosensitive Gel Enhance In Vivo Dermal Wound Healing via Activation of the VEGF/PI3K/Akt and TGF-β/Smads Signaling Pathway

1First College of Clinical Medicine, Nanjing University of Chinese Medicine, No. 138, Xianlin Avenue, Nanjing 210023, China
2College of Pharmacy, Nanjing University of Chinese Medicine, No. 138, Xianlin Avenue, Nanjing 210023, China

Correspondence should be addressed to Li-Qun Pan; moc.361@ena_rc

Received 11 May 2017; Revised 16 July 2017; Accepted 17 August 2017; Published 24 October 2017

Academic Editor: Elia Ranzato

Copyright © 2017 Meng-Di Cui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. G. Ovington, “Advances in wound dressings,” Clinics in Dermatology, vol. 25, no. 1, pp. 33–38, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. S.-Z. Fu, X.-H. Meng, J. Fan et al., “Acceleration of dermal wound healing by using electrospun curcumin-loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) fibrous mats,” Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 102, no. 3, pp. 533–542, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. X. Li, R. Fan, A. Tong et al., “In situ gel-forming AP-57 peptide delivery system for cutaneous wound healing,” International Journal of Pharmaceutics, vol. 495, no. 1, pp. 560–571, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. N. Mohamad, M. C. I. Mohd Amin, M. Pandey, N. Ahmad, and N. F. Rajab, “Bacterial cellulose/acrylic acid hydrogel synthesized via electron beam irradiation: accelerated burn wound healing in an animal model,” Carbohydrate Polymers, vol. 114, pp. 312–320, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. J. P. Silva, S. Dhall, M. Garcia et al., “Improved burn wound healing by the antimicrobial peptide LLKKK18 released from conjugates with dextrin embedded in a carbopol gel,” Acta Biomaterialia, vol. 26, pp. 249–262, 2015. View at Publisher · View at Google Scholar · View at Scopus
  6. J. A. Hubbell, “Hydrogel systems for barriers and local drug delivery in the control of wound healing,” Journal of Controlled Release, vol. 39, no. 2-3, pp. 305–313, 1996. View at Publisher · View at Google Scholar · View at Scopus
  7. S. P. Miguel, M. P. Ribeiro, H. Brancal, P. Coutinho, and I. J. Correia, “Thermoresponsive chitosan-agarose hydrogel for skin regeneration,” Carbohydrate Polymers, vol. 111, pp. 366–373, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Yu, Q.-M. Wang, X. Wang et al., “Liposome incorporated ion sensitive in situ gels for opthalmic delivery of timolol maleate,” International Journal of Pharmaceutics, vol. 480, no. 1-2, pp. 128–136, 2015. View at Publisher · View at Google Scholar · View at Scopus
  9. S. GuhaSarkar, P. More, and R. Banerjee, “Urothelium-adherent, ion-triggered liposome-in-gel system as a platform for intravesical drug delivery,” Journal of Controlled Release, vol. 245, pp. 147–156, 2017. View at Publisher · View at Google Scholar · View at Scopus
  10. P. N. Gupta, A. Pattani, R. M. Curran et al., “Development of liposome gel based formulations for intravaginal delivery of the recombinant HIV-1 envelope protein CN54gp140,” European Journal of Pharmaceutical Sciences, vol. 46, no. 5, pp. 315–322, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. Z. Qin and S.-Q. Huang, “Influence of drug-serum containing Dangguibuxue decoction on functional activity and PI3K/Akt pathway of endothelial progenitor cells,” Chinese Pharmacological Bulletin, vol. 29, no. 9, pp. 1320–1323, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Lei, Q. Gao, Y.-S. Li, and K.-J. Chen, “Study on effects of Astragalus, Angelica and their combination on vascular endothelial cell proliferation in vitro,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 23, no. 10, pp. 753–756, 2003. View at Google Scholar
  13. H.-J. Chen and L.-Q. Pan, “Effect observation of collagen sponge with Angelica microcapsules for replenishing blood to promote wound healing,” Chinese Pharmacological Bulletin, vol. 32, no. 12, pp. 1775-1776, 2016. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Bochot, E. Fattal, J. L. Grossiord, F. Puisieux, and P. Couvreur, “Characterization of a new ocular delivery system based on a dispersion of liposomes in a thermosensitive gel,” International Journal of Pharmaceutics, vol. 162, no. 1-2, pp. 119–127, 1998. View at Publisher · View at Google Scholar
  15. Z.-H. Pan, M.-D. Cui, L.-Q. Pan, Y. Zhang, and Y. Pan, “Simultaneous determination of three active components in Danggui Buxue decoction by HPLC-DAD/ELSD method,” Lishizhen Medicine and Materia Medica Research, vol. 27, no. 3, pp. 547–550, 2016. View at Google Scholar
  16. Z. A. Amin, H. M. Ali, M. A. Alshawsh, P. H. Darvish, and M. A. Abdulla, “Application of Antrodia camphorata promotes rat’s wound healing in vivo and facilitates fibroblast cell proliferation in vitro,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 317693, 14 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. R. E. Neuman and M. A. Logan, “The determination of hydroxyproline,” The Journal of Biological Chemistry, vol. 184, no. 1, pp. 299–306, 1950. View at Google Scholar · View at Scopus
  18. I. Majewska and E. Gendaszewska-Darmach, “Proangiogenic activity of plant extracts in accelerating wound healing—a new face of old phytomedicines,” Acta Biochimica Polonica, vol. 58, no. 4, pp. 449–460, 2011. View at Google Scholar · View at Scopus
  19. X. Luo, P. Huang, B. Yuan et al., “Astragaloside IV enhances diabetic wound healing involving upregulation of alternatively activated macrophages,” International Immunopharmacology, vol. 35, pp. 22–28, 2016. View at Publisher · View at Google Scholar · View at Scopus
  20. C.-Y. Hsiao, C.-Y. Hung, T.-H. Tsai, and K.-F. Chak, “A study of the wound healing mechanism of a traditional chinese medicine, Angelica sinensis, using a proteomic approach,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 467531, 14 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. T. W. Lau, Y. W. Chan, C. P. Lau et al., “Investigation of the effects of Chinese medicine on fibroblast viability: implications in wound healing,” Phytotherapy Research, vol. 21, no. 10, pp. 938–947, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. K.-M. Lau, K.-K. Lai, C.-L. Liu et al., “Synergistic interaction between Astragali Radix and Rehmanniae Radix in a Chinese herbal formula to promote diabetic wound healing,” Journal of Ethnopharmacology, vol. 141, no. 1, pp. 250–256, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. H.-W. Lam, H.-C. Lin, S.-C. Lao et al., “The angiogenic effects of Angelica sinensis extract on HUVEC in vitro and Zebrafish in vivo,” Journal of Cellular Biochemistry, vol. 103, no. 1, pp. 195–211, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Lai, J. Chan, H.-F. Kwok et al., “Induction of angiogenesis in zebrafish embryos and proliferation of endothelial cells by an active fraction isolated from the root of Astragalus membranaceus using bioassayguided fractionation,” Journal of Traditional and Complementary Medicine, vol. 4, no. 4, pp. 239–245, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. P. Martin, “Wound healing—aiming for perfect skin regeneration,” Science, vol. 276, no. 5309, pp. 75–81, 1997. View at Publisher · View at Google Scholar · View at Scopus
  26. E. M. C. SantAna, C. M. C. P. Gouvêa, C. R. Nakaie, and H. S. Selistre-de-Araújo, “Angiogenesis and growth factor modulation induced by alternagin C, a snake venom disintegrin-like, cysteine-rich protein on a rat skin wound model,” Archives of Biochemistry and Biophysics, vol. 479, no. 1, pp. 20–27, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. A.-K. Olsson, A. Dimberg, J. Kreuger, and L. Claesson-Welsh, “VEGF receptor signalling—in control of vascular function,” Nature Reviews Molecular Cell Biology, vol. 7, no. 5, pp. 359–371, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. X. Zhao, H. Wu, B. Guo, R. Dong, Y. Qiu, and P. X. Ma, “Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing,” Biomaterials, vol. 122, pp. 34–47, 2017. View at Publisher · View at Google Scholar · View at Scopus
  29. H.-M. Shen, C. Chen, J.-Y. Jiang et al., “The N-butyl alcohol extract from Hibiscus rosa-sinensis L. flowers enhances healing potential on rat excisional wounds,” Journal of Ethnopharmacology, vol. 198, pp. 291–301, 2017. View at Publisher · View at Google Scholar · View at Scopus
  30. S.-H. Lee, M. Zahoor, J.-K. Hwang, D. S. Min, and K.-Y. Choi, “Valproic acid induces cutaneous wound healing in vivo and enhances keratinocyte motility,” PLoS ONE, vol. 7, no. 11, Article ID e48791, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. H.-L. Yang, Y.-C. Tsai, M. Korivi, C.-T. Chang, and Y.-C. Hseu, “Lucidone Promotes the Cutaneous Wound Healing Process via Activation of the PI3K/AKT, Wnt/β-catenin and NF-κB Signaling Pathways,” Biochimica et Biophysica Acta (BBA)—Molecular Cell Research, vol. 1864, no. 1, pp. 151–168, 2017. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Barrientos, O. Stojadinovic, M. S. Golinko, H. Brem, and M. Tomic-Canic, “Growth factors and cytokines in wound healing,” Wound Repair and Regeneration, vol. 16, no. 5, pp. 585–601, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. Z. B. Kryger, M. Sisco, N. K. Roy, L. Lu, D. Rosenberg, and T. A. Mustoe, “Temporal expression of the transforming growth factor-beta pathway in the rabbit ear model of wound healing and scarring,” Journal of the American College of Surgeons, vol. 205, no. 1, pp. 78–88, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Upadhyay, P. Chattopadhyay, D. Goyary, P. M. Mazumder, and V. Veer, “Eleutherine indica L. accelerates in vivo cutaneous wound healing by stimulating Smad-mediated collagen production,” Journal of Ethnopharmacology, vol. 146, no. 2, pp. 490–494, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. Q. Zhang, C. C. Fong, W. K. Yu et al., “Herbal formula Astragali Radix and Rehmanniae Radix exerted wound healing effect on human skin fibroblast cell line Hs27 via the activation of transformation growth factor (TGF-β) pathway and promoting extracellular matrix (ECM) deposition,” Phytomedicine, vol. 20, no. 1, pp. 9–16, 2012. View at Publisher · View at Google Scholar · View at Scopus