In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of Nigella sativa

Table 3

Variation in serum biochemical parameters in Rattus norvegicus. Effect of AqE.NS (2 g/kg) after induction of diabetes with alloxan.

	T0	W3	W4t	W8t
Glycemia (mg/dL)
C
DM
DNS
Triglycerides (mg/dL)
C				81.68 0,46
DM		141.61 6,47		157.28 ± 1.9
DNS				75.53 ± 3.5
Total cholesterol (mg/dL)
C				60,86 0.69
DM				114.61 7.91
DNS				72.41 7.78
HDL-c (mmol/L)
C
DM
DNS
LDL-c (mmol/L)
C
DM
DNS
Insulinemia (UI)
C			-
DM			-
DNS			-
AST (U/L)
C				147.7 32.54
DM				128.5 11.65
DNS				137.43 16.47
ALT (U/L)
C				60.01 0,73
DM				78.81 4.36
DNS				40.35 1,23
Sera TBARS (µM/L)
C			-
DM
DNS
Erythrocytic TBARS (µM/L)
C
DM			14.78 ± 5.27
DNS	12.00 ± 1.48	12.06 ± 1.64	9.40 ± 1.96	7.9 ± 0.65

Values are expressed as means SM. C: control group; DM: diabetic rats model; DNS: diabetic rats treated with 2 g AqE.NS/Kg body weight; T0: initial time of experiment; W3: 3 weeks after injection of alloxan; W1t to W8t: weeks of treatment by AqE.NS after induction of diabetes in the third group, DNS.