Gengnianchun, a Traditional Chinese Medicine, Enhances Oxidative Stress Resistance and Lifespan in Caenorhabditis elegans by Modulating daf-16/FOXO

Table 2

Survival time data under oxidative stress: effects of GNC treatment on wild-type and mutant C. elegans.

Strain	Treatment (mg/mL)	Mean survival hours (±SEM)	Worms ()	% change	value
N2	Control	25.83 ± 0.71	92	67	<0.0001
	3.94-GNC	43.13 ± 1.17	90
eat-2 (ad465)	Control	35.69 ± 0.68	89	32	<0.0001
	3.94-GNC	46.95 ± 0.90	91
rsks-1 (ok1255)	Control	37.39 ± 0.69	98	39	<0.0001
	3.94-GNC	51.88 ± 1.02	99
isp-1 (qm150)	Control	20.40 ± 0.71	90	42	<0.0001
	3.94-GNC	28.94 ± 0.72	94
nuo-6 (qm200)	Control	19.09 ± 0.57	92	47	<0.0001
	3.94-GNC	28.04 ± 0.72	98
glp-1 (e2144)	Control	30.54 ± 0.62	95	24	<0.0001
	3.94-GNC	37.92 ± 0.76	96
daf-16 (mu86)	Control	19.60 ± 0.63	90	0.06	0.2311
	3.94-GNC	20.74 ± 0.70	92
daf-2 (e1370)	Control	51.43 ± 1.56	91	28	<0.0001
	3.94-GNC	65.87 ± 1.76	92
age-1 (hx546)	Control	45.82 ± 1.31	97	21	<0.0001
	3.94-GNC	55.61 ± 1.51	92