Research Article
Fraction n-Butanol of Radix Notoginseng Protects PC12 Cells from Aβ25–35-Induced Cytotoxicity and Alleviates Cognitive Deficits in SAMP8 Mice by Attenuating Oxidative Stress and Aβ Accumulation
Figure 1
Effect of fraction NB on proliferation and Aβ25–35 induced cytotoxicity in PC12 cells. (a) Effects of the fractions isolated from Radix Notoginseng on proliferation of PC12 cells. (b) Cells were pretreated with fraction NB (10–80 μg/mL) for 24 h before being incubated with 10 μM Aβ25–35 and OD values were measured using the MTT assay. (c) Cells were with 10 μM Aβ25–35 for 24 h and then posttreated with 10–80 μg/mL fraction NB for 72 h and OD values were measured using the MTT assay. The data in different groups were expressed as the mean ± SD from 3 experiments. Statistical difference between groups was assessed by -test using the SPSS 13.0 software. , versus the control group; , versus Aβ25–35-treated group.
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