Fraction n-Butanol of Radix Notoginseng Protects PC12 Cells from A<i>β</i><sub>25–35</sub>-Induced Cytotoxicity and Alleviates Cognitive Deficits in SAMP8 Mice by Attenuating Oxidative Stress and A<i>β</i> Accumulation

<div>Assessment of acute toxicity of fraction NB using single dose acute assay. (a) Body weights of fraction NB-treated and control mice. Mice were given fraction NB at a single dose of 194.5 g/kg. Body weight of each mouse was recorded on days 1, 7, and 14 after treatment. (b) Relative organ weights of liver, heart, spleen, and kidney. On day 14 after treatment, mice were ethically sacrificed and heart, liver, spleen, and kidney were excised. Relative organ weights of liver, heart, spleen, and kidney were calculated. Data in each experiment represent mean ± SD from 20 independent samples. Statistically significant differences were calculated by one-way ANOVA using the SPSS 13.0 software.</div>

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Figure 2: Fraction n-Butanol of Radix Notoginseng Protects PC12 Cells from A<i>β</i><sub>25–35</sub>-Induced Cytotoxicity and Alleviates Cognitive Deficits in SAMP8 Mice by Attenuating Oxidative Stress and A<i>β</i> Accumulation 

Figure 2 | Fraction n-Butanol of Radix Notoginseng Protects PC12 Cells from Aβ25–35-Induced Cytotoxicity and Alleviates Cognitive Deficits in SAMP8 Mice by Attenuating Oxidative Stress and Aβ Accumulation 