Research Article
Fraction n-Butanol of Radix Notoginseng Protects PC12 Cells from Aβ25–35-Induced Cytotoxicity and Alleviates Cognitive Deficits in SAMP8 Mice by Attenuating Oxidative Stress and Aβ Accumulation
Figure 4
(a) Effect of fraction NB on Aβ accumulation in SAMP8 mice brains. After treatment with fraction NB, the level of Aβ in the brains of SAMP8 mice was detected using ELISA assay. ((b) and (c)) Effect of fraction NB on SOD and GSH-PX activities in the brains of SAMP8 mice. After treatment with fraction NB, the activities of SOD and GSH-PX were measured using activity detection kit. ((d) and (e)) Effect of fraction NB on APP and BACE1 mRNA expressions. Data in each experiment represent mean ± SD from 4-5 independent samples. Statistically significant differences were calculated by one-way ANOVA using the SPSS 13.0 software. , , versus the control group; , versus the model group.
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