Neuroprotective Properties of Panax notoginseng Saponins via Preventing Oxidative Stress Injury in SAMP8 Mice

Figure 2

Effects of PNS on oxidative stress injury in SAMP8 mice. (a) Immunohistochemical analysis of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-PX) expressions in the hippocampal CA1 region, respectively (scale bar = 25 μm); (b and c) the percentages of immunopositive neurons and activities of SOD, CAT, and GSH-PX, respectively; (d) 8-hydroxydeoxyguanosine (8-OHdG) production; (e and f) uncoupling protein 4 (UCP4) and UCP5 protein expressions, respectively; (g and h) UCP4 and UCP5 mRNA expressions, respectively. Data in each experiment represent mean ± SD from 4-5 independent samples. Statistically significant differences were calculated by one-way ANOVA using the SPSS 13.0 software. and , versus control group; and , versus model group.

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