Study of the Hypoglycemic Activity of Derivatives of Isoflavones from Cicer arietinum L.

Figure 2

Synthetic routes. Reagents and conditions: (a) (CH₃CO)₂O, Py, reflux 4 h; (b) DCC, Py, reflux, 80°C, 4 h. (c) ClCH₂COCl, NaHCO₃, EA, r.t., 0.5 h; (d) K₂CO₃, KI, DMF, 24 h. (e) CCl₄/Et₃N, C₂H₅OH, 24 h. (f) K₂CO₃, CH₃CH₂OH, reflux 24 h. (g) DCC, Py, reflux, 80°C, 4 h. (h) CH₃OH, 60°C, 1 h; (i) VO(acac)₂, r.t., 0.5 h; (j) stand in air for a few days for crystallization. Parent compounds: R = OH, H; R′ = H, OCH₃.