Resveratrol Attenuates Microglial Activation via SIRT1-SOCS1 Pathway

Figure 1

Resveratrol reduced iNOS expression and restored cell viability in the microglial cells exposed to LPS plus IFNγ. (a) The N9 microglial cells were divided into five groups, including 10 ng/ml LPS plus 10 U/ml IFNγ (LPS/IFNγ) exposure group, and four concentrations of resveratrol (RSV) treatment groups (5 μM, 10 μM, 25 μM, and 50 μM). After 24 h incubation, western blot analysis was taken to evaluate the iNOS protein expression in the cells . (b) The cells were divided into six groups, including control, LPS/IFNγ, and four concentrations of resveratrol (RSV) treatment groups (5 μM, 10 μM, 25 μM, and 50 μM). After 24 h incubation, MTT assay was taken to evaluate the cell viability . Results are expressed as means ± SD. ; NS: no significance.

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