Evaluation of Analgesic Activity of Papaver libanoticum Extract in Mice: Involvement of Opioids Receptors

Table 2

Analgesic effect of different doses of PLE by hot plate method in mice.

Treatment	Reaction time (sec, mean ± SEM)
	0 hrs	0.5 hrs	1 hr	1.5 hrs	2 hrs	3 hrs	4 hrs	6 hrs	8 hrs	24 hrs
Control	9.4 ± 0.54	9.64 ± 0.91	9.82 ± 0.68	10.04 ± 0.42	10 ± 0.7	9.5 ± 0.65	10.44 ± 0.93	10.66 ± 0.65	10.2 ± 0.28	9.15 ± 0.35
PLE 12.5 mg/kg	8.6 ± 0.75	8.23 ± 0.65	9.67 ± 1	10.13 ± 0.64	9.87 ± 1.53	10.87 ± 2.14	10.1 ± 1.51	10.8 ± 1.91	10.77 ± 1.96	9.57 ± 1.1
PLE 25 mg/kg	9.32 ± 0.86	9.84 ± 1.04	11.22 ± 1.36	11.24 ± 1.2	12.50 ± 1.12	13.5 ± 0.56	12.92 ± 0.77	12.22 ± 0.62	11.5 ± 0.42	10.55 ± 0.21
PLE 50 mg/kg	8.53 ± 0.77	11.52 ± 1.64	13.28 ± 1.02	14.65 ± 0.82	15.85 ± 2.03	16.32 ± 1.37	15.72 ± 1.45	14.5 ± 1.26	12.55 ± 1.06	10.55 ± 0.64
PLE 75 mg/kg	8.63 ± 0.6	11.33 ± 1.72	13.23 ± 0.67	15.67 ± 0.31	16.87 ± 2.1	18.07 ± 1.92	16.8 ± 2	15.47 ± 1.21	13.83 ± 1.16	11 ± 0.2
PLE 100 mg/kg	9.82 ± 0.95	12.84 ± 1.79	14.76 ± 2.38	16.76 ± 2.09	18.4 ± 1.29	20.2 ± 2.31	18.08 ± 1.04	16.18 ± 1.87	14.7 ± 0.71	12.8 ± 0.57
PLE 150 mg/kg	8.83 ± 1	12.27 ± 1.92	14.77 ± 1.44	17.2 ± 2.35	20.27 ± 2.77	21.3 ± 3.11	18.87 ± 1.86	16.7 ± 0.44	15.83 ± 0.35	13.33 ± 0.61
PLE 200 mg/kg	9.88 ± 0.75	13.37 ± 2.46	15.53 ± 1.04	20.03 ± 3.59	22.85 ± 4.4	24 ± 4.41	21.78 ± 3.9	17.68 ± 1.01	15.9 ± 0.99	14.15 ± 1.06
Morphine (5 mg/kg)	9.72 ± 0.68	24.05 ± 2.67	24.03 ± 2.4	22.08 ± 1.44	20.7 ± 2.69	18.15 ± 1.14	14 ± 2.39	13.8 ± 1.08	10.8 ± 0.28	9.4 ± 0.28

; ().