Evaluation of Analgesic Activity of Papaver libanoticum Extract in Mice: Involvement of Opioids Receptors

Table 4

Effect of naloxone on analgesic activity of PLE using tail flick method in mice.

Treatment	Reaction time (sec, mean ± SEM)
	0 hrs	0.5 hrs	1 hr	1.5 hrs	2 hrs	3 hrs	4 hrs	6 hrs
Control (vehicle)	2.64	2.72	2.54	2.92	2.74	2.74	2.82	2.72
Naloxone (4 mg/kg)	2.68 ± 0.5	2.70 ± 0.3	2.62 ± 0.29	2.88 ± 0.19	2.62 ± 0.18	2.54 ± 0.34	2.94 ± 0.27	3.16 ± 0.29
Morphine 5 mg/kg	2.64 ± 0.24	11.04 ± 2.14	9.82 ± 1.3	8.06 ± 0.99	6.68 ± 1.48	4.46 ± 0.99	3.64 ± 0.71	3.92 ± 1.17
PLE 100 mg/kg	2.87 ± 0.17	3.51 ± 0.24	4.20 ± 0.76	5.84 ± 0.66	7.09 ± 0.8	7.46 ± 0.82	6.09 ± 0.94	5.53 ± 0.78
Naloxone + morphine	2.44 ± 0.27	2.88 ± 0.63	3.12 ± 0.67	3.30 ± 0.89	3.08 ± 0.64	3.24 ± 0.43	3.18 ± 0.43	3.32 ± 0.43
Naloxone + PLE	2.55 ± 0.23	2.63 ± 0.21	2.67 ± 0.33	2.85 ± 0.26	2.70 ± 0.35	2.72 ± 0.35	2.65 ± 0.59	2.93 ± 0.28

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