Research Article
Evaluation of Analgesic Activity of Papaver libanoticum Extract in Mice: Involvement of Opioids Receptors
Table 5
Effect of naloxone on analgesic activity of PLE using hot plate method in mice.
| Treatment | Reaction time (sec, mean ± SEM) | 0 hrs | 0.5 hrs | 1 hr | 1.5 hrs | 2 hrs | 3 hrs | 4 hrs | 6 hrs |
| Control (vehicle) | 8.7 | 9.12 | 9.38 | 9.94 | 9.14 | 9.46 | 9.92 | 10.22 | Naloxone (4 mg/kg) | 8.56 ± 0.92 | 9.52 ± 0.98 | 9.76 ± 1.16 | 9.50 ± 0.86 | 9.44 ± 0.71 | 9.46 ± 0.63 | 9.96 ± 0.74 | 10.56 ± 0.36 | Morphine 5 mg/kg | 9 ± 0.77 | 23.33 ± 1.89 | 23.5 ± 4.45 | 21.67 ± 2.95 | 19.27 ± 2.28 | 18.02 ± 1.23 | 14.25 ± 0.93 | 13.67 ± 1.32 | PLE 100 mg/kg | 9.68 ± 0.92 | 14.15 ± 1.09 | 15.30 ± 2.99 | 17.62 ± 4.43 | 19.33 ± 2.56 | 20.7 ± 2.58 | 17.88 ± 2.34 | 14.57 ± 1.5 | Naloxone + morphine | 7.86 ± 0.74 | 8.92 ± 0.53 | 8.72 ± 0.25 | 8.72 ± 1.28 | 8.42 ± 1.43 | 8.78 ± 1.57 | 8.48 ± 0.85 | 8.70 ± 0.93 | Naloxone + PLE | 7.63 ± 0.68 | 7.77 ± 0.74 | 9.57 ± 2.08 | 9.52 ± 1.59 | 9.68 ± 1.38 | 9.62 ± 0.98 | 9.22 ± 1.02 | 9.38 ± 1.36 |
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