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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 8971746, 9 pages
https://doi.org/10.1155/2017/8971746
Research Article

Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial

1UniEvangélica University Center, Anápolis, GO, Brazil
2University of Brasilia (UnB), Brasilia, DF, Brazil
3Laboratory of Research, Development and Innovation, Apis Flora Indl. Coml. Ltda., Ribeirão Preto, SP, Brazil
4University of São Paulo (USP), Ribeirão Preto Medical School, Ribeirão Preto, SP, Brazil

Correspondence should be addressed to Eduardo B. Coelho; rb.psu.prmf@ohleocbe

Received 6 December 2016; Revised 20 February 2017; Accepted 26 February 2017; Published 15 March 2017

Academic Editor: Letizia Angiolella

Copyright © 2017 Gisela de M. S. Pina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Our hypothesis tested the efficacy and safety of a mucoadhesive oral gel formulation of Brazilian propolis extract compared to miconazole oral gel for the treatment of denture stomatitis due to Candida spp. infection in older adults. Forty patients were randomly allocated in a noninferiority clinical trial into two groups. The control group (MIC) received 20 mg/g miconazole oral gel and the study group (PROP) received mucoadhesive formulation containing standardized extract of 2% (20 mg/g) propolis (EPP-AF®) during 14 days. Patients were examined on days 1, 7, and 14. The Newton’s score was used to classify the severity of denture stomatitis. The colony forming unity count (CFU/mL) was quantified and identified (CHROMagar Candida®) before and after the treatment. Baseline characteristics did not differ between groups. Both treatments reduced Newton’s score (), indicating a clinical improvement of the symptoms of candidiasis with a clinical cure rate of 70%. The microbiological cure with significant reduction in fungal burden on T14 was 70% in the miconazole group and 25% in the EPP-AF group. The EPP-AF appears to be noninferior to miconazole considering the clinical cure rate and could be recommended as an alternative treatment in older patients.