Pharmacokinetics of Caffeic Acid, Ferulic Acid, Formononetin, Cryptotanshinone, and Tanshinone IIA after Oral Administration of Naoxintong Capsule in Rat by HPLC-MS/MS

Table 1

Source and MRM parameters of the eleven compounds and four ISs.

Compounds	Parameter
	CUR	CAD	IS	TEM	GS1	GS2	Q1	Q3	DP(V)	EP(V)	CE(V)	CXP(V)
Paeoniflorin	20	8	−4500	500	30	30	478.6	121.1	−45	−4	−30	−1
Ecdysterone	20	8	−4500	500	30	30	478.9	159.0	−60	−10	−37	−1
Amygdalin	20	8	−4500	500	30	30	455.8	322.8	−50	−4.5	−20	−22
Mulberroside A	20	8	−4500	500	30	30	567.0	242.6	−60	−10	−38	−16
Caffeic acid	20	8	−4500	500	30	30	178.9	134.9	−35	−3.5	−24	−0.5
Ferulic acid	20	8	−4500	500	30	30	192.8	133.9	−31	−4	−23	−1
Salvianolic acid B	20	8	−4500	500	30	30	716.5	518.5	−55	−4.5	−25	−40
astragaloside IV	10	8	5000	500	40	30	807.0	807.0	140	10	50	55
Formononetin	20	8	−4500	500	30	30	267.0	251.8	−60	−2	−27	−16
Cryptotanshinone	10	8	5000	500	40	30	297.0	254.2	50	9	35	15
Tanshinone IIA	10	8	5000	500	40	30	295.2	277.1	58	10	27	21
Geniposide	20	8	−4500	500	30	30	387.0	224.7	−40	−9	−15	−15
Sennoside B	20	8	−4500	500	30	30	860.6	385.9	−87	−10	−60	−2
Puerarin	20	8	−4500	500	30	30	414.8	266.9	−50	−9	−46	−2
Chlorogenic acid	20	8	−4500	500	30	30	352.8	190.9	−33	−4	−32	−2