Figure 7: Red maca methanolic extract (MetOH) and its butanolic (ButOH) and aqueous (Aq) fractions have a positive estrogenic effect by balancing ERα and ERβ expression levels, but Aq also possesses an androgenic effect increasing AR levels, and, due to this, its positive estrogenic effect and thus its action against BPH would be blocked (dashed truncated arrows), due to an acute increment of ERα levels and by interfering with ERβ pathways (dotted truncated and normal arrow).