N-Butanol and Aqueous Fractions of Red Maca Methanolic Extract Exerts Opposite Effects on Androgen and Oestrogens Receptors (Alpha and Beta) in Rats with Testosterone-Induced Benign Prostatic Hyperplasia

<div>Red maca methanolic extract (MetOH) and its butanolic (ButOH) and aqueous (Aq) fractions have a positive estrogenic effect by balancing ER<i>α</i> and ER<i>β</i> expression levels, but Aq also possesses an androgenic effect increasing AR levels, and, due to this, its positive estrogenic effect and thus its action against BPH would be blocked (dashed truncated arrows), due to an acute increment of ER<i>α</i> levels and by interfering with ER<i>β</i> pathways (dotted truncated and normal arrow).</div>

Evidence-Based Complementary and Alternative Medicine

fig7

Figure 7

Figure 7: N-Butanol and Aqueous Fractions of Red Maca Methanolic Extract Exerts Opposite Effects on Androgen and Oestrogens Receptors (Alpha and Beta) in Rats with Testosterone-Induced Benign Prostatic Hyperplasia 

Figure 7 | N-Butanol and Aqueous Fractions of Red Maca Methanolic Extract Exerts Opposite Effects on Androgen and Oestrogens Receptors (Alpha and Beta) in Rats with Testosterone-Induced Benign Prostatic Hyperplasia 