Research Article

Potential Antitumor Effect of Harmine in the Treatment of Thyroid Cancer

Figure 10

Antitumor effect of harmine in TPC-1 xenograft models. Tumor volume of established TPC-1 xenografts in nude mice during therapy under different treatments. Mice were treated with different protocols on Day 0 as shown in the figure. Saline: vehicle; harmine was administered at the doses of 10, 20, and 40 mg/kg. Different agents were delivered through intravenous pathway when tumor volume measured 100 mm3. Data are presented as mean SD (). The difference between tumor volumes in the group of saline and either 20 or 40 mg/kg of harmine is significant ( means versus control). Significant difference (# means ) also is observed between the groups receiving 40 mg/kg and 20 mg/kg harmine.