Review Article
The Characteristics of TCM Clinical Trials: A Systematic Review of ClinicalTrials.gov
Table 1
Characteristics of TCM interventional studies.
| | Parameter | Number/total number (%) | | All trials | Oct 2000–Sep 2005 | Oct 2005–Sep 2010 | Oct 2010–Sep 2015 |
| | Primary purpose, N | | | | | | Treatment | 970/1270 (76.4) | 77/95 (81.1) | 305/396 (77.0) | 588/779 (75.5) | | Prevention | 96/1270 (7.6) | 3/95 (3.2) | 30/396 (7.6) | 63/779 (8.1) | | Other purpose | 168/1270 (13.2) | 11/95 (11.6) | 50/396 (12.6) | 107/779 (13.7) | | Missing | 36/1270 (2.8) | 4/95 (4.2) | 11/396 (2.8) | 21/779 (2.7) | | Phase, N | | | | | | Phase 0 | 18/1270 (1.4) | 1/95 (1.1) | 3/396 (0.8) | 14/779 (1.8) | | Phase 1 | 67/1270 (5.3) | 12/95 (12.6) | 23/396 (5.8) | 32/779 (4.1) | | Phase 1/phase 2 | 61/1270 (4.8) | 10/95 (10.5) | 24/396 (6.1) | 27/779 (3.5) | | Phase 2 | 203/1270 (16.0) | 28/95 (29.5) | 71/396 (17.9) | 104/779 (13.4) | | Phase 2/phase 3 | 62/1270 (4.9) | 3/95 (3.2) | 22/396 (5.6) | 37/779 (4.7) | | Phase 3 | 131/1270 (10.3) | 22/95 (23.2) | 44/396 (11.1) | 65/779 (8.3) | | Phase 4 | 101/1270 (8.0) | 1/95 (1.1) | 23/396 (5.8) | 77/779 (9.9) | | Missing | 627/1270 (49.4) | 18/95 (18.9) | 186/396 (47.0) | 423/779 (54.3) | | Sex/age, N | | | | | | Female | 206/1270 (16.2) | 17/95 (17.9) | 72/396 (18.2) | 117/779 (15.0) | | Male | 20/1270 (1.6) | 1/95 (1.1) | 6/396 (1.5) | 13/779 (1.7) | | Both | 1044/1270 (82.2) | 77/95 (81.1) | 318/396 (80.3) | 649/779 (83.3) | | Overall status, N | | | | | | Not yet recruiting | 96/1270 (7.6) | 1/95 (1.1) | 9/396 (2.3) | 86/779 (11.0) | | Recruiting | 442/1270 (34.8) | 3/95 (3.2) | 71/396 (17.9) | 368/779 (47.2) | | Active, not recruiting | 76/1270 (6.0) | 1/95 (1.1) | 26/396 (6.6) | 49/779 (6.3) | | Completed | 574/1270 (45.2) | 81/95 (85.3) | 260/396 (65.7) | 233/779 (29.9) | | Terminated | 40/1270 (3.1) | 7/95 (7.4) | 20/396 (5.1) | 13/779 (1.7) | | Suspended | 6/1270 (0.5) | 1/95 (1.1) | 3/396 (0.8) | 2/779 (0.3) | | Withdrawn | 10/1270 (0.8) | 1/95 (1.1) | 4/396 (1.0) | 5/779 (0.6) | | Enrolling by invitation | 26/1270 (2.0) | 0 | 3/396 (0.8) | 23/779 (3.0) | | Study result , N | | | | | | Has result | 50/574 (8.7) | 2/81 (2.5) | 33/260 (12.7) | 15/233 (6.4) | | DMC, N | | | | | | Has DMC | 637/1270 (50.2) | 10/95 (10.5) | 179/396 (45.2) | 448/779 (57.5) | | No DMC | 442/1270 (34.8) | 8/95 (8.4) | 151/396 (38.1) | 283/779 (36.3) | | DMC missing | 191/1270 (15.0) | 77/95 (81.1) | 66/396 (16.7) | 48/779 (6.2) |
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Only including the completed studies.
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