Efficacy and Safety of Modified Banxia Xiexin Decoction (Pinellia Decoction for Draining the Heart) for Gastroesophageal Reflux Disease in Adults: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the studies included in the meta-analysis.

Study ID (first author, year)	Classification of GERD	Type of syndrome	Sample size		Age (years)	Course of disease	Duration	Intervention		Outcome measures
			EG (M/F)	CG (M/F)				EG	CG
He and Han 2016 [29]	NERD	Stagnated heat in liver and stomach syndrome	45 (26/19)	45 (29/16)	21–68	2 days–102 days	8 weeks	Modified Banxia Xiexin; decoction, 100 mL, b.i.d	PPIs	①④⑤
Shou 2015 [30]	N/A	N/A	43 (24/19)	43 (23/20)	E: C:	1 year–10 years	60 d	Banxia Xiexin; decoction, 100 mL, t.i.d	PPIs + 5-HT4RA	①⑥
Yang et al. 2015 [31]	RE	N/A	70 (38/32)	69 (35/34)	E: C:	E: C:	3 months	Modified Banxia Xiexin; decoction plus Sini Powder, b.i.d	PPIs + D2RA	②③⑥
Wang et al. 2013 [32]	N/A	Cold and heat mixed type	56 (30/26)	56 (32/24)	22–64	1 year–12 years	8 weeks	Modified Banxia Xiexin; decoction, b.i.d + point injection (vitamin B6), q.o.d	PPIs + D2RA	①②⑦
Chen 2013 [33]	N/A	Stagnation of liver and stomach Qi, stomachache due to cold, deficiency of stomach, yin, hyperactivity of stomach, heat, syndrome of retention of food in stomach	E:C 58/58; M:F 70/46		21–68	0.5 year–13 years	4 weeks	Modified Banxia Xiexin; decoction, b.i.d	PPIs + 5-HT4RA	①⑥
Sun et al. 2013 [34]	N/A	N/A	30 (17/13)	30 (14/16)	21–61	1 year–6 years	30 d	Modified Banxia Xiexin; decoction	PPIs + D2RA	①②⑥⑧
Cao 2013 [35]	RE	N/A	32 (26/6)	32 (22/10)	Mentioned	N/A	8 weeks	Modified Banxia Xiexin; decoction, 1 dose/d	D2RA + H2RA	①②⑥
Zhu et al. 2012 [36]	RE	N/A	60 (32/28)	60 (29/31)	19–72	3 months–12 years	4 weeks	Banxia Xiexin decoction plus Xuanfu Daizhe decoction, 250 mL, b.i.d	PPIs	①⑥
Shen 2012 [37]	RE	Cold and heat mixed type	43 (27/16)	40 (26/14)	26–70	N/A	56 days	Modified Banxia Xiexin decoction, 100 mL, b.i.d	PPIs + D2RA	①⑨
Lu et al. 2010 [38]	RE	Stomach Qi rising	39 (20/19)	39 (19/20)	20–65	1–6 years	4 weeks	Modified Banxia Xiexin decoction, b.i.d	PPIs + 5-HT4RA	①②⑥
Chen et al. 2009 [39]	RE	N/A	90 (56/34)	60 (39/21)	18–69	2–10 weeks	8 months	Modified Banxia Xiexin decoction, 150 mL, b.i.d	PPIs	①②③⑥⑨
Huang and Wu 2007 [40]	RE	N/A	60 (35/25)	60 (38/22)	18–61	2 months–30 years	8 weeks	Modified Banxia Xiexin decoction, b.i.d	PPIs + 5-HT4RA	①

①: overall clinical efficacy; ②: efficacy under gastroscope; ③: recurrence rate; ④: RDQ, SAS, and SDS grading; ⑤: SF-36 dimensions of grading; ⑥: symptom integrals; ⑦: plasma GAS level; ⑧: pathological effect; ⑨: RE classification in gastroscopy; GERD: gastroesophageal reflux disease; NERD: nonerosive reflux disease; RE: reflux esophagitis; M: male; F: female; EG: experiment group; CG: control group; N/A: not applicable; RDQ: reflux disease diagnostic questionnaire; SAS: self-rating anxiety scale; SDS: self-rating depression scale; PPIs: proton pump inhibitors; 5-HT₄RA: 5-HT₄ receptor agonists; D₂RA: D₂ receptor antagonists; H₂RA: H₂ receptor antagonists.