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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 9708094, 10 pages
https://doi.org/10.1155/2017/9708094
Research Article

Antihypertensive and Antihypertrophic Effects of Acupuncture at PC6 Acupoints in Spontaneously Hypertensive Rats and the Underlying Mechanisms

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, 16 Nanxiaojie, Dongzhimennei, Beijing 100700, China

Correspondence should be addressed to Xiao-Chun Yu; nc.ca.mctnic.liam@cxuy

Received 20 September 2016; Accepted 15 January 2017; Published 15 February 2017

Academic Editor: Maria Camilla Bergonzi

Copyright © 2017 Juan-Juan Xin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. B. Zhang, Q. J. Du, H. Li et al., “The therapeutic effect of Rosuvastatin on cardiac remodelling from hypertrophy to fibrosis during the end-stage hypertension in rats,” Journal of Cellular and Molecular Medicine, vol. 16, no. 9, pp. 2227–2237, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. L. Paulis and T. Unger, “Novel therapeutic targets for hypertension,” Nature Reviews Cardiology, vol. 7, no. 8, pp. 431–441, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. F. M. Fouad, J. M. Slominski, and R. C. Tarazi, “Left ventricular diastolic function in hypertension: relation to left ventricular mass and systolic function,” Journal of the American College of Cardiology, vol. 3, no. 6, pp. 1500–1506, 1984. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Mancia, C. Giannattasio, and G. Grassi, “Hypertension, left ventricular hypertrophy and heart failure,” Annali Italiani di Medicina Interna, vol. 8, 1993. View at Google Scholar · View at Scopus
  5. L. T. Skeggs, F. E. Dorer, J. R. Kahn, K. E. Lentz, and M. Levine, “The biochemistry of the renin-angiotensin system and its role in hypertension,” The American Journal of Medicine, vol. 60, no. 6, pp. 737–748, 1976. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Unger, L. Paulis, and D. A. Sica, “Therapeutic perspectives in hypertension: novel means for renin-angiotensin-aldosterone system modulation and emerging device-based approaches,” European Heart Journal, vol. 32, no. 22, pp. 2739–2747, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Wolf-Maier, R. S. Cooper, H. Kramer et al., “Hypertension treatment and control in five european countries, Canada, and the United States,” Hypertension, vol. 43, no. 1, pp. 10–17, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. P. Li, S. C. Tjen-A-Looi, L. Cheng et al., “Long-lasting reduction of blood pressure by electroacupuncture in patients with hypertension: randomized controlled trial,” Medical Acupuncture, vol. 27, no. 4, pp. 253–266, 2015. View at Publisher · View at Google Scholar · View at Scopus
  9. F. A. Flachskampf, J. Gallasch, O. Gefeller et al., “Randomized trial of acupuncture to lower blood pressure,” Circulation, vol. 115, no. 24, pp. 3121–3129, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. X. Lai, J. Wang, N. R. Nabar et al., “Proteomic response to acupuncture treatment in spontaneously hypertensive rats,” PLoS ONE, vol. 7, no. 9, Article ID e44216, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. M. S. Lee, H. S. Hwang, Y. S. Kim et al., “Electroacupuncture delays hypertension development through enhancing NO/NOS activity in spontaneously hypertensive rats,” Evidence-based Complementary and Alternative Medicine, vol. 2011, Article ID 130529, 7 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. Z.-J. Huo, Q. Li, G.-H. Tian et al., “The ameliorating effects of long-term electroacupuncture on cardiovascular remodeling in spontaneously hypertensive rats,” BMC Complementary and Alternative Medicine, vol. 14, article 118, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Gao, Y. Zhao, Y. Wang et al., “Anti-arrhythmic effect of acupuncture pretreatment in the rats subjected to simulative global ischemia and reperfusion-involvement of intracellular Ca2+ and connexin 43,” BMC Complementary and Alternative Medicine, vol. 15, no. 1, article no. 5, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Li, R. Shibata, S. Maruyama et al., “Fenofibrate promotes ischemia-induced revascularization through the adiponectin-dependent pathway,” American Journal of Physiology—Endocrinology and Metabolism, vol. 299, no. 4, pp. E560–E566, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. G.-Y. Lv, Y.-P. Zhang, J.-L. Gao et al., “Combined antihypertensive effect of luteolin and buddleoside enriched extracts in spontaneously hypertensive rats,” Journal of Ethnopharmacology, vol. 150, no. 2, pp. 507–513, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. D. J. Sahn, A. DeMaria, J. Kisslo, and A. Weyman, “Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements,” Circulation, vol. 58, no. 6, pp. 1072–1083, 1978. View at Publisher · View at Google Scholar · View at Scopus
  17. F. Prunier, R. Gaertner, L. Louedec, J.-B. Michel, J.-J. Mercadier, and B. Escoubet, “Doppler echocardiographic estimation of left ventricular end-diastolic pressure after MI in rats,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 283, no. 1, pp. H346–H352, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Chen, X. Wu, S. Yu et al., “Neuroprotective capabilities of tanshinone IIA against cerebral ischemia/reperfusion injury via anti-apoptotic pathway in rats,” Biological and Pharmaceutical Bulletin, vol. 35, no. 2, pp. 164–170, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Takemori, Y. Hasegawa, J. Katahira, K. Nakao, and T. Inukai, “Effect of benazepril hydrochloride on cardiac hypertrophy in spontaneously hypertensive rats,” Arzneimittel-Forschung/Drug Research, vol. 41, no. 6, pp. 612–615, 1991. View at Google Scholar · View at Scopus
  20. R. Bahr, H. Blumberg, and W. Jänig, “Do dichotomizing afferent fibers exist which supply visceral organs as well as somatic structures? A contribution to the problem of referred pain,” Neuroscience Letters, vol. 24, no. 1, pp. 25–28, 1981. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Cervero and L. A. Connell, “Distribution of somatic and visceral primary afferent fibres within the thoracic spinal cord of the cat,” Journal of Comparative Neurology, vol. 230, no. 1, pp. 88–98, 1984. View at Publisher · View at Google Scholar · View at Scopus
  22. P. Li, K. F. Pitsillides, S. V. Rendig, H.-L. Pan, and J. C. Longhurst, “Reversal of reflex-induced myocardial ischemia by median nerve stimulation: a feline model of electroacupuncture,” Circulation, vol. 97, no. 12, pp. 1186–1194, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Li and J. C. Longhurst, “Neural mechanism of electroacupuncture's hypotensive effects,” Autonomic Neuroscience: Basic and Clinical, vol. 157, no. 1-2, pp. 24–30, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. S. C. Tjen-A-Looi, P. Li, and J. C. Longhurst, “Role of medullary GABA, opioids, and nociceptin in prolonged inhibition of cardiovascular sympathoexcitatory reflexes during electroacupuncture in cats,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 293, no. 6, pp. H3627–H3635, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. P. Li, S. C. Tjen-A-Looi, and J. C. Longhurst, “Nucleus raphé pallidus participates in midbrain-medullary cardiovascular sympathoinhibition during electroacupuncture,” American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 299, no. 5, pp. R1369–R1376, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. D. B. Matchar, D. C. McCrory, L. A. Orlando et al., “Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension,” Annals of Internal Medicine, vol. 148, no. 1, pp. 16–29, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Unger, “The role of the renin-angiotensin system in the development of cardiovascular disease,” American Journal of Cardiology, vol. 89, no. 2, pp. 3A–10A, 2002. View at Google Scholar
  28. Z. H. Israili and W. Dallas Hall, “Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy: a review of the literature and pathophysiology,” Annals of Internal Medicine, vol. 117, no. 3, pp. 234–242, 1992. View at Publisher · View at Google Scholar · View at Scopus
  29. W. Zhou and J. C. Longhurst, “Neuroendocrine mechanisms of acupuncture in the treatment of hypertension,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 878673, 9 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. C. Yin, B. Seo, H. J. Park et al., “Acupuncture, a promising adjunctive therapy for essential hypertension: a double-blind, randomized, controlled trial,” Neurological Research, vol. 29, supplement 1, pp. S98–S103, 2007. View at Google Scholar
  31. H. S. Hwang, Y. S. Kim, Y. H. Ryu et al., “Electroacupuncture delays hypertension development through enhancing NO/NOS activity in spontaneously hypertensive rats,” Evidence-based Complementary and Alternative Medicine, vol. 2011, Article ID 130529, 7 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. L. S. N. Chang, T. J. Ho, M. A. Shibu et al., “Protective effects of electroacupuncture at LR3 on cardiac hypertrophy and apoptosis in hypertensive rats,” Acupuncture in Medicine, vol. 34, no. 3, pp. 201–208, 2016. View at Google Scholar
  33. X. Xiong, C. You, Q.-C. Feng et al., “Pulse width modulation electro-acupuncture on cardiovascular remodeling and plasma nitric oxide in spontaneously hypertensive rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 812160, 6 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. G.-H. Tian, K. Sun, P. Huang et al., “Long-term stimulation with electroacupuncture at DU20 and ST36 rescues hippocampal neuron through attenuating cerebral blood flow in spontaneously hypertensive rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 482947, 10 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. Z.-J. Huo, Q. Li, G.-H. Tian et al., “The ameliorating effects of long-term electroacupuncture on cardiovascular remodeling in spontaneously hypertensive rats,” BMC Complementary and Alternative Medicine, vol. 14, article no. 118, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. C.-R. Zhang, C.-M. Xia, M.-Y. Jiang et al., “Repeated electroacupuncture attenuating of apelin expression and function in the rostral ventrolateral medulla in stress-induced hypertensive rats,” Brain Research Bulletin, vol. 97, pp. 53–62, 2013. View at Publisher · View at Google Scholar · View at Scopus