Integrative Approach to Facilitate Fracture Healing: Topical Chinese Herbal Paste with Oral Strontium Ranelate

Figure 3

Cell proliferation at different concentrations of CDR or SrR assessed by BrdU assay. CDR or SrR alone on (a) UMR106 and (b) BMSC, and control (Ctrl) is 0 μg/ml. Cotreatment of CDR (200 or 400 μg/ml) with varying concentrations of SrR on (c) UMR106 and (d) BMSC, and control (Ctrl) is the cells incubated with medium without drug (CDR and SrR). Data are expressed as mean ± SD (error bar). , , versus Ctrl; , ^##, versus 0 μg/ml of SrR at (c) and (d). The horizontal straight line indicates the groups beneath sharing the same statistical significance.

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