Evidence-Based Complementary and Alternative Medicine / 2017 / Article / Tab 2

Research Article

Potent Phosphodiesterase Inhibition and Nitric Oxide Release Stimulation of Anti-Impotence Thai Medicinal Plants from “MANOSROI III” Database

Table 2

Phosphodiesterases (PDEs) inhibition and nitric oxide (NO) release stimulation activities of the fifteen selected plant extracts.

NumberSamplesInhibition of PDEs activityStimulation of NO release
%IC50 (mg/mL)%SC50 (mg/mL)
Mean ± S.D.Folds of sildenafilMean ± SDFolds of sildenafilMean ± SDFolds of acetylcholineMean ± SDFolds of acetylcholine

1EDP1-001(1)0.0026±0.00252.23
2EDP1-001(2)
3EDP1-001(3)
4EDP1-002(1)
5EDP1-002(2)
6EDP1-003
7EDP1-004
8EDP2-001(1)
9EDP2-001(2)
10EDP2-001(3)
11EDP2-002(1)
12EDP2-002(2)
13EDP2-003(1)
14EDP2-003(2)
15EDP2-003(3)

16Sildenafil1

17Acetylcholine11

18L-NAME

Inhibition of PDEs activity: inhibition percentages were determined at the concentrations of the extracts and sildenafil at 200 and 0.45 µg/mL, respectively. IC50 was the concentrations of samples giving 50% inhibition of the PDEs activity. The minus value indicated the stimulation of PDEs. Stimulation of NO release: stimulation percentages of the extracts, acetylcholine, and L-NAME were tested at the concentration of 1 mg/mL. SC50 was the concentrations of samples giving 50% stimulation of the NO production activity. L-NAME was -nitro-L-arginine methyl ester hydrochloride (NO release inhibitor). The minus value indicated the inhibition of NO production.

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