Chloroform Extract of Artemisia annua L. Relaxes Mouse Airway Smooth Muscle

Figure 2

CEAA blocks high K⁺-evoked Ca²⁺ influx. (a) A representative force tracing of 4 TRs/4 mice. Under Ca²⁺-free conditions (0 Ca²⁺ and 0.5 mM EGTA), high K⁺ failed to elicit contraction in a tracheal ring. Following restoration of 2 mM Ca²⁺, a sustained contraction occurred, and it was completely inhibited by 0.316 mg/ml CEAA. (b) Identical experiments were performed as described in the presence of 0.316 mg/ml CEAA, and high K⁺-induced contraction did not appear after the restoration of 2 mM Ca²⁺.

(a)

(b)