The Effect of Electroacupuncture versus Manual Acupuncture through the Expression of TrkB/NF-κB in the Subgranular Zone of the Dentate Gyrus of Telomerase-Deficient Mice

Figure 2

Acupuncture intervention prevented spatial and memory impairment in telomerase-deficient mice (Terc^−/−) in Morris water maze task. (a) Performance in training trial of Terc^−/− mice ( for each subgroup) and (b) wild-type mice ( for each subgroup), during 4-day hidden platform trial. The data shows that escape latency to reach the hidden platform before acupuncture intervention in three subgroups. (c) In the probe test, the difference value of time spent in the target quadrant between before and after treatment was calculated. It was interesting that the EA stimulation can significantly increase the time in target quadrant for Terc^−/− mice , while nothing changed in WT mice. (d) There was also no significant difference among each subgroup for WT mice, and, compared with CON group, EA stimulation could significantly increase the -value of frequency of locating platform between before and after treatment .

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