Preclinical Evaluation of In Vitro and In Vivo Antiviral Activities of KCT-01, a New Herbal Formula against Hepatitis B Virus

Figure 3

Suppression of virion particle production and pgRNA synthesis by KCT-01 in HepG2.2.15 cells. (a-b) HepG2.2.15 cells were treated with KCT-01 (0, 25, or 250 μg/ml) or ETV (100 μM) for 48 h. Levels of 3.5 kb pgRNA (a) and viral DNAs (b) were quantified by qPCR. Values are provided as mean ± S.D.s of triplicated experiments. Statistical significance was processed using Student’s t-test. p < 0.05 and p < 0.001 compared to ETV-treated group.

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(b)