Δ³,2-Hydroxybakuchiol Attenuates Depression in Multiple Rodent Models Possibly by Inhibition of Monoamine Transporters in Brain

Figure 4

Δ³,2-Hydroxybakuchiol increased sucrose preference. Except for nonstressed group (Non-CUMS/Vehicle), Sprague-Dawley rats underwent CUMS procedure for 8 weeks (n = 10). All rats underwent SCT and daily intraperitoneal injection of vehicle, Δ³,2-hydroxybakuchiol, or bupropion with indicated dosages after the first 4-week stress procedure. Data was obtained before treatment (week 0) and after 2-week treatment and 4-week treatment. Values are expressed in the percentage of Non-CUMS/Vehicle group as mean ±  SEM. Compared with Non-CUMS/Vehicle group, +P < 0.05 and ++P < 0.01; compared with CUMS/Vehicle group, P < 0.05, P < 0.01, and P < 0.005.