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Evidence-Based Complementary and Alternative Medicine
Volume 2018 (2018), Article ID 1413940, 10 pages
https://doi.org/10.1155/2018/1413940
Research Article

Effect of Lavender (Lavandula angustifolia) Essential Oil on Acute Inflammatory Response

1Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, Brazil
2College of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil
3Department of Chemistry, State University of Maringá, Maringá, PR, Brazil

Correspondence should be addressed to Saulo Euclides Silva-Filho; moc.liamg@fse.oluas

Received 14 November 2017; Revised 31 January 2018; Accepted 6 February 2018; Published 18 March 2018

Academic Editor: Junji Xu

Copyright © 2018 Gabriel Fernando Esteves Cardia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Lavandula angustifolia is a plant of Lamiaceae family, with many therapeutic properties and biological activities, such as anticonvulsant, anxiolytic, antioxidant, anti-inflammatory, and antimicrobial activities. The aim of this study was to evaluate the effect of Lavandula angustifolia Mill. essential oil (LEO) on acute inflammatory response. LEO was analyzed using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR) methods and showed predominance of 1,8-cineole (39.83%), borneol (22.63%), and camphor (22.12%). LEO at concentrations of 0.5, 1, 3, and 10 μg/ml did not present in vitro cytotoxicity. Additionally, LEO did not stimulate the leukocyte chemotaxis in vitro. The LEO topical application at concentrations of 0.25, 0.5, and 1 mg/ear reduced edema formation, myeloperoxidase (MPO) activity, and nitric oxide (NO) production in croton oil-induced ear edema model. In carrageenan-induced paw edema model, LEO treatment at doses of 75, 100, and 250 mg/kg reduced edema formation, MPO activity, and NO production. In dextran-induced paw edema model, LEO at doses of 75 and 100 mg/kg reduced paw edema and MPO activity. In conclusion, LEO presented anti-inflammatory activity, and the mechanism proposed of LEO seems to be, at least in part, involving the participation of prostanoids, NO, proinflammatory cytokines, and histamine.