Inhibition of Aortic Intimal Hyperplasia and Vascular Smooth Muscle Proliferation and Extracellular Matrix Protein Expressions by Astragalus–Angelica Combination

Figure 1

Comparison of intimal hyperplasia among the groups. (a) Pathological morphology of blood vessels (Masson staining, ×100, Bar=200μm). (b) Comparison of morphometric indexes of vessels among the groups (±s, n=8). 1. Normal. 2. Model. 3. Astragalus (2.17g/kg). 4. Angelica (1.08g/kg). 5. Astragalus–Angelica 1:2 (Astragalus 1.3g/kg + Angelica 2.6g/kg). 6. Astragalus–Angelica 1:5 (Astragalus 0.65g/kg + Angelica 3.25g/kg). 7. Astragalus–Angelica 1:1 (Astragalus 1.95g/kg + Angelica 1.95g/kg). 8. Astragalus–Angelica 5:1 (Astragalus 3.25g/kg + Angelica 0.65g/kg). 9. Astragalus–Angelica 2:1 (Astragalus 2.6g/kg + Angelica 1.3/kg). 10. Atorvastatin (10mg/kg). (A) Intimal area (IA). (B) Intimal thickness (IT). (C) Hyperplasia ratio of intimal area (HRIA). (D) Hyperplasia ratio of intimal thickness (HRIT). ^※P < 0.05, ^※※P < 0.01 versus normal group; ^■P < 0.05, ^■■P < 0.01 versus model group; ^□P < 0.05, ^□□P < 0.01 versus Atorvastatin group.

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