Inhibition of Aortic Intimal Hyperplasia and Vascular Smooth Muscle Proliferation and Extracellular Matrix Protein Expressions by Astragalus–Angelica Combination

<div>Comparison of cell cycle-related proteins cyclin D1 and cyclin E expressions in vascular tissues among the groups (<svg height="8.8553pt" id="M16" style="vertical-align:-0.04981995pt" version="1.1" viewbox="-0.0498162 -8.80548 6.28474 8.8553" width="6.28474pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><rect height="0.65243" width="6.1851" x="0" y="-8.10323"></rect><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M474 0V26C414 34 401 43 364 100L267 248C300 297 324 332 345 358C381 400 394 405 455 411V437H272V411C316 406 323 401 305 370C287 337 267 306 247 276L188 369C169 397 173 405 215 411V437H16V411C71 404 83 396 114 348L201 212C171 167 144 127 116 92C77 42 66 34 4 26V0H190V26C139 34 136 43 156 77C175 113 198 150 220 183L294 66C311 39 302 31 260 26V0H474Z" id="g121-118"></path></g></svg>±s, n = 6). (a) Western-blotting patterns of cyclin D1 and cyclin E protein. (b) Comparison of cyclin D1 and cyclin E protein expressions: 1. Normal. 2. Model. 3. Astragalus. 4. Angelica. 5. Astragalus–Angelica 1:1. 6. Astragalus–Angelica 5:1. 7. Atorvastatin. ※P &lt; 0.05, ※※P &lt; 0.01 versus normal group; ■P &lt; 0.05, ■■P &lt; 0.01 versus model group; □P &lt; 0.05, □□P &lt; 0.01 versus Atorvastatin group.</div>

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Figure 4

Figure 4: Inhibition of Aortic Intimal Hyperplasia and Vascular Smooth Muscle Proliferation and Extracellular Matrix Protein Expressions by Astragalus–Angelica Combination 

Figure 4 | Inhibition of Aortic Intimal Hyperplasia and Vascular Smooth Muscle Proliferation and Extracellular Matrix Protein Expressions by Astragalus–Angelica Combination 