A Systematic Review about the Efficacy and Safety of Tripterygium wilfordii Hook.f. Preparations Used for the Management of Rheumatoid Arthritis

Table 2

The results of the included studies through sensitivity analysis.

Excluded study	TWPs group (number)	Control group (number)	RR/MD (95% CI)	P value	Heterogeneity test	Effect model
Effectiveness
Before excluding	950	516	1.20 [1.13, 1.27]	P < 0.00001	P = 0.19, = 31%	Fixed
Cao, 2015	811	373	1.25 [1.16, 1.34]	P < 0.00001	P = 0.86, = 0%	Fixed
Jiao et al., 2016	871	436	1.18 [1.10, 1.25]	P < 0.00001	P = 0.37, = 7%	Fixed
Li et al., 2009	897	462	1.19 [1.12, 1.26]	P < 0.00001	P = 0.15, = 38%	Fixed
Lv et al., 2014	881	447	1.20 [1.13, 1.27]	P < 0.00001	P = 0.12, = 43%	Fixed
Meng et al., 2013	900	466	1.20 [1.13, 1.27]	P < 0.00001	P = 0.12, = 43%	Fixed
Yang and Zhang, 2007	890	456	1.19 [1.12, 1.26]	P < 0.00001	P = 0.15, = 38%	Fixed
Zhou and Yuan, 2013	450	456	1.20 [1.12, 1.28]	P < 0.00001	P = 0.12, = 43%	Fixed
Toxicity
Before excluding	978	542	0.83 [0.70, 0.98]	P = 0.03	P = 0.54, = 0%	Fixed
Cao, 2015	839	399	0.80 [0.65, 0.98]	P = 0.03	P = 0.47, = 0%	Fixed
Jiang et al., 2015	950	516	0.84 [0.71, 0.99]	P = 0.04	P = 0.54, = 0%	Fixed
Jiao et al., 2016	899	462	0.80 [0.67, 0.95]	P = 0.009	P = 0.85, = 0%	Fixed
Li et al., 2009	925	488	0.83 [0.70, 0.99]	P = 0.03	P = 0.42, = 0%	Fixed
Lv et al., 2014	909	473	0.86 [0.70, 1.05]	P = 0.13	P = 0.49, = 0%	Fixed
Meng et al., 2013	928	492	0.83 [0.70, 0.99]	P = 0.03	P = 0.43, = 0%	Fixed
Yang and Zhang, 2007	918	482	0.86 [0.72, 1.02]	P = 0.08	P = 0.55, = 0%	Fixed
Zhou and Yuan, 2013	478	482	0.82 [0.67, 1.01]	P = 0.06	P = 0.43, = 0%	Fixed
ESR
Before excluding	985	531	−3.59 [−6.72, −0.46]	P = 0.02	P = 0.0006, = 71%	Random
Cao, 2015	847	389	−4.02 [−7.37, −0.68]	P = 0.02	P = 0.001, = 71%	Random
Jiao et al., 2016	906	471	−4.46 [−7.48, −1.44]	P = 0.004	P = 0.004, = 67%	Random
Li et al., 2009	932	477	−3.25 [−6.97, 0.46]	P = 0.09	P = 0.0003, = 74%	Random
Lv et al., 2014	916	462	−3.22 [−6.64, 0.21]	P = 0.07	P = 0.0003, = 74%	Random
Meng et al., 2013	935	481	−3.15 [−7.10, 0.79]	P = 0.12	P = 0.0003, = 74%	Random
Wang, 2004	979	525	−4.02 [−7.30, −0.73]	P = 0.02	P = 0.0008, = 72%	Random
Wang et al., 2013	955	501	−4.09 [−7.15, −1.03]	P = 0.009	P = 0.001, = 71%	Random
Yang and Zhang, 2007	925	471	−3.21 [−6.74, 0.32]	P = 0.08	P = 0.0003, = 74%	Random
Zhou and Yuan, 2013	485	471	−3.38 [−5.08, −1.69]	P < 0.0001	P = 0.10, = 41%	Fixed
RF
Before excluding	197	202	−5.41 [−7.46, −3.37]	P < 0.00001	P = 0.31, = 13%	Fixed
Cao, 2015	59	60	−5.47 [−7.51, −3.42]	P < 0.00001	P = 0.25, = 25%	Fixed
Li et al., 2009	144	148	5.46 [−9.49, 20.41]	P = 0.47	P = 0.62, = 0%	Fixed
Wang, 2004	191	196	−5.57 [−7.63, −3.51]	P < 0.00001	P = 0.32, = 0%	Fixed
CRP
Before excluding	405	411	−1.03 [−1.76, −0.29]	P = 0.006	P = 0.01, = 62%	Random
Cao, 2015	268	269	−1.08 [−1.83, −0.33]	P = 0.005	P = 0.010, = 67%	Random
Li et al., 2009	352	357	−0.77 [−1.48, −0.06]	P = 0.03	P = 0.04, = 57%	Random
Lv et al., 2014	336	342	-0.99 [-1.71, -0.26]	P = 0.008	P = 0.01, = 66%	Random
Meng et al., 2013	355	361	-1.22 [-1.54, -0.89]	P < 0.00001	P = 0.36, = 9%	Fixed
Wang, 2004	399	405	-1.07 [-1.83, -0.31]	P = 0.006	P = 0.008, = 68%	Random
Wang et al., 2013	375	381	-0.99 [-1.76, -0.23]	P = 0.01	P = 0.008, = 68%	Random
Yang and Zhang, 2007	345	351	-1.08 [-2.44, 0.27]	P = 0.12	P = 0.07, = 51%	Random