Ginsenoside Rg3 Sensitizes Colorectal Cancer to Radiotherapy through Downregulation of Proliferative and Angiogenic Biomarkers

Figure 4

Rg3 downregulates the expression of NF-κB-regulated gene products in colorectal tumor samples. Western blots showing that combined Rg3 and radiation treatment inhibits the expression of the NF-κB-dependent antiapoptotic gene products survivin; angiogenic gene product VEGF; and proliferative gene products such as COX-2 and cyclin D1. (a) Representative blot, (b) the quantitative analysis for the expression of NF-κB-regulated gene products. < 0.05, < 0.01, and < 0.001. Data represent mean ± SEM. All above experiments were repeated at least four times.

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