A Component Formula of Chinese Medicine for Hypercholesterolemia Based on Virtual Screening and Biology Network

Table 2

The validation results of each pharmacophore model.

Name	Feature	Specificity	Energy	An	Dn	Ha	Ht	HRA	IEI	CAI
M-HMG-CoA reductase-1	AH3Ev14	—	—	92	375	52	72	0.56	2.94	1.66
M-HMG-CoA reductase-2	AH3Ev14	—	—	92	375	60	203	0.25	1.20	0.79
M-SQS-1	A3DH2Ev18	—	—	96	329	41	54	0.43	2.60	1.11
M-SQS-2	A3DH2Ev18	—	—	96	329	54	140	0.56	0.56	0.74
M-SREBP-1	A2DH3	3.7	6.26	20	60	20	40	100	2.00	2
M-SREBP-2	A2DH3	3.9	3.79	20	60	20	24	100	3.33	3.33
M-SREBP-3	A2DH3	4.6	5.17	20	60	20	22	100	3.64	3.64

^aAn: active compounds number. ^bDn: all compounds in test number. ^cHa: hit active compounds number. ^dHt: hit compounds number. ^eHRA: the hit ratio of active compounds. ^fIEI: identification of effective index. ^gCAI: comprehensive appraisal index.