Evaluation of the Wound Healing Activity of the Crude Extract of Leaves of Acanthus polystachyus Delile (Acanthaceae)

Table 1

Effect of topical application of the 80% methanolic extract of the leaves of A. polystachyus on wound contraction of excision wound model in mice.

	Days	SO	NF	5 CEO	10 CEO
Wound area (mm^2), after wounding days	0	301.21 ± 6.14	301.21 ± 6.14	298.70 ± 6.84	301.21 ± 6.14
	2	278.81 ± 9.13	264.55 ± 12.29	273.71 ± 6.12	264.02 ± 6.12
	4	240.61 ± 6.14	210.38 ± 12.7	222.81 ± 8.16	209.60 ± 5.46
	6	214.18 ± 8.62	155.96 ± 15.43	165.51 ± 7.55	123.63 ± 9.97
	8	169.56 ± 9.56	91.32 ± 11.85	98.78 ± 8.57	64.89 ± 8.17
	10	130.71±12.31	48.80 ± 4.65	52.99 ± 5.05	24.08 ± 5.39
	12	94.07 ± 12.43	23.81 ± 4.76	23.68 ± 47.09	3.40 ± 1.29
	14	50.89 ± 10.02	4.97 ± 1.99	7.07 ± 3.18	0.00 ± 0.00
	16	31.01± 5.38	0.00 ± 0.00	1.70 ± 1.18	0.00 ± 0.00

SO, simple ointment base; CEO, crude extract ointment; NF, nitrofurazone; = 6 animals in each group. Values are expressed as mean ± SEM (n = 6), one-way ANOVA. Against control and against 5% (w/w) hydroalcoholic extract; P < 0.05, P < 0.01, and P < 0.001.